Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (plexauridae)

Hsu Ming Chung; Li Chung Hu; Wei Hsuan Yen; Jui Hsin Su; Mei Chin Lu; Tsong Long Hwang; Wei Hsien Wang; Ping Jyun Sung

doi:10.3390/md10102246

Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (plexauridae)

Hsu Ming Chung, Li Chung Hu, Wei Hsuan Yen, Jui Hsin Su, Mei Chin Lu, Tsong Long Hwang, Wei Hsien Wang^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.

Original language	English
Pages (from-to)	2246-2253
Number of pages	8
Journal	Marine Drugs
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/md10102246
State	Published - 10 2012

Keywords

Cytotoxicity
Echinohalimane
Echinomuricea
Elastase
Halimane

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title = "Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (plexauridae)",

abstract = "A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.",

keywords = "Cytotoxicity, Echinohalimane, Echinomuricea, Elastase, Halimane",

author = "Chung, {Hsu Ming} and Hu, {Li Chung} and Yen, {Wei Hsuan} and Su, {Jui Hsin} and Lu, {Mei Chin} and Hwang, {Tsong Long} and Wang, {Wei Hsien} and Sung, {Ping Jyun}",

year = "2012",

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doi = "10.3390/md10102246",

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T1 - Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (plexauridae)

AU - Chung, Hsu Ming

AU - Hu, Li Chung

AU - Yen, Wei Hsuan

AU - Su, Jui Hsin

AU - Lu, Mei Chin

AU - Hwang, Tsong Long

AU - Wang, Wei Hsien

AU - Sung, Ping Jyun

PY - 2012/10

Y1 - 2012/10

N2 - A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.

AB - A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.

KW - Cytotoxicity

KW - Echinohalimane

KW - Echinomuricea

KW - Elastase

KW - Halimane

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DO - 10.3390/md10102246

M3 - 文章

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AN - SCOPUS:84868241591

SN - 1660-3397

VL - 10

SP - 2246

EP - 2253

JO - Marine Drugs

JF - Marine Drugs

IS - 10

ER -

Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (plexauridae)

Abstract

Keywords

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