Editorial expression of concern: Trypsin-induced proteome alteration during cell subculture in mammalian cells

Hsiang Ling Huang; Hsiang Wei Hsing; Tzu Chia Lai; Yi Wen Chen; Tian Ren Lee; Hsin Tsu Chan; Ping Chiang Lyu; Chieh Lin Wu; Ying Chieh Lu; Szu Ting Lin; Cheng Wen Lin; Chih Ho Lai; Hao Teng Chang; Hsiu Chuan Chou; Hong Lin Chan

doi:10.1186/s12929-026-01285-4

Editorial expression of concern: Trypsin-induced proteome alteration during cell subculture in mammalian cells

Hsiang Ling Huang
, Hsiang Wei Hsing
, Tzu Chia Lai
, Yi Wen Chen
, Tian Ren Lee
, Hsin Tsu Chan
, Ping Chiang Lyu
, Chieh Lin Wu
, Ying Chieh Lu
, Szu Ting Lin
, Cheng Wen Lin
, Chih Ho Lai
, Hao Teng Chang
, Hsiu Chuan Chou^*
, Hong Lin Chan^*

^*Corresponding author for this work

National Tsing Hua University
China Medical University Taichung

Research output: Contribution to journal › Comment/debate

Abstract

The Editors would like to alert the readers that concerns have been raised regarding the Figure 4. Specifically, Figure 4 VDAC2 appears to be very similar with Figure 1A pp38 in a previous publication [1]. The authors are not able to provide original data so the images could not be verified. Readers are advised to interpret these results with caution. Authors Hsiang-Ling Huang and Hong-Lin Chan agree to this Editorial Expression of Concern. The rest of the authors have not responded to correspondence regarding this Editorial Expression of Concern.

Original language	English
Article number	85
Journal	Journal of Biomedical Science
Volume	33
Issue number	1
DOIs	https://doi.org/10.1186/s12929-026-01285-4
State	Published - 24 08 2026
Externally published	Yes

Bibliographical note

Publisher Copyright:
The Author(s) 2026.

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Huang, H. L., Hsing, H. W., Lai, T. C., Chen, Y. W., Lee, T. R., Chan, H. T., Lyu, P. C., Wu, C. L., Lu, Y. C., Lin, S. T., Lin, C. W., Lai, C. H., Chang, H. T., Chou, H. C., & Chan, H. L. (2026). Editorial expression of concern: Trypsin-induced proteome alteration during cell subculture in mammalian cells. Journal of Biomedical Science, 33(1), Article 85. https://doi.org/10.1186/s12929-026-01285-4

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title = "Editorial expression of concern: Trypsin-induced proteome alteration during cell subculture in mammalian cells",

abstract = "The Editors would like to alert the readers that concerns have been raised regarding the Figure 4. Specifically, Figure 4 VDAC2 appears to be very similar with Figure 1A pp38 in a previous publication [1]. The authors are not able to provide original data so the images could not be verified. Readers are advised to interpret these results with caution. Authors Hsiang-Ling Huang and Hong-Lin Chan agree to this Editorial Expression of Concern. The rest of the authors have not responded to correspondence regarding this Editorial Expression of Concern. The Author(s) 2026.",

author = "Huang, \{Hsiang Ling\} and Hsing, \{Hsiang Wei\} and Lai, \{Tzu Chia\} and Chen, \{Yi Wen\} and Lee, \{Tian Ren\} and Chan, \{Hsin Tsu\} and Lyu, \{Ping Chiang\} and Wu, \{Chieh Lin\} and Lu, \{Ying Chieh\} and Lin, \{Szu Ting\} and Lin, \{Cheng Wen\} and Lai, \{Chih Ho\} and Chang, \{Hao Teng\} and Chou, \{Hsiu Chuan\} and Chan, \{Hong Lin\}",

note = "Publisher Copyright: The Author(s) 2026.",

year = "2026",

month = aug,

day = "24",

doi = "10.1186/s12929-026-01285-4",

language = "英语",

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T2 - Trypsin-induced proteome alteration during cell subculture in mammalian cells

AU - Huang, Hsiang Ling

AU - Hsing, Hsiang Wei

AU - Lai, Tzu Chia

AU - Chen, Yi Wen

AU - Lee, Tian Ren

AU - Chan, Hsin Tsu

AU - Lyu, Ping Chiang

AU - Wu, Chieh Lin

AU - Lu, Ying Chieh

AU - Lin, Szu Ting

AU - Lin, Cheng Wen

AU - Lai, Chih Ho

AU - Chang, Hao Teng

AU - Chou, Hsiu Chuan

AU - Chan, Hong Lin

PY - 2026/8/24

Y1 - 2026/8/24

N2 - The Editors would like to alert the readers that concerns have been raised regarding the Figure 4. Specifically, Figure 4 VDAC2 appears to be very similar with Figure 1A pp38 in a previous publication [1]. The authors are not able to provide original data so the images could not be verified. Readers are advised to interpret these results with caution. Authors Hsiang-Ling Huang and Hong-Lin Chan agree to this Editorial Expression of Concern. The rest of the authors have not responded to correspondence regarding this Editorial Expression of Concern. The Author(s) 2026.

AB - The Editors would like to alert the readers that concerns have been raised regarding the Figure 4. Specifically, Figure 4 VDAC2 appears to be very similar with Figure 1A pp38 in a previous publication [1]. The authors are not able to provide original data so the images could not be verified. Readers are advised to interpret these results with caution. Authors Hsiang-Ling Huang and Hong-Lin Chan agree to this Editorial Expression of Concern. The rest of the authors have not responded to correspondence regarding this Editorial Expression of Concern. The Author(s) 2026.

UR - https://www.scopus.com/pages/publications/105048717628

U2 - 10.1186/s12929-026-01285-4

DO - 10.1186/s12929-026-01285-4

M3 - 评论/辩论

C2 - 42638109

AN - SCOPUS:105048717628

SN - 1021-7770

VL - 33

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

IS - 1

M1 - 85

ER -

Editorial expression of concern: Trypsin-induced proteome alteration during cell subculture in mammalian cells

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Bibliographical note

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