Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang; Peng Nien Huang; Hui Chen Hung; Sung Nien Tseng; Chia Chia Chang; Ya Ru Tsai; Yun Ming Wang; Shin Ru Shih; John Tsu An Hsu

doi:10.1128/AAC.00695-20

Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang
, Peng Nien Huang
, Hui Chen Hung
, Sung Nien Tseng
, Chia Chia Chang
, Ya Ru Tsai
, Yun Ming Wang
, Shin Ru Shih
, John Tsu An Hsu^*

^*Corresponding author for this work

National Yang Ming Chiao Tung University
Industrial Technology Research Institute of Taiwan
National Health Research Institutes Taiwan
Chang Gung University
Council of Agriculture Taiwan

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Original language	English
Article number	e00695-20
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00695-20
State	Published - 01 2021

Bibliographical note

Publisher Copyright:
© 2020 American Society for Microbiology. All Rights Reserved.

Keywords

Antiviral research
Decoy receptor
Enterovirus A71
Neuropilin 1
Virus receptor trap

Access to Document

10.1128/AAC.00695-20

Cite this

@article{8edaec4b6a0c4afb8be0b74f913750b1,

title = "Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro",

abstract = "We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.",

keywords = "Antiviral research, Decoy receptor, Enterovirus A71, Neuropilin 1, Virus receptor trap",

author = "Wang, \{Hsiang Ching\} and Huang, \{Peng Nien\} and Hung, \{Hui Chen\} and Tseng, \{Sung Nien\} and Chang, \{Chia Chia\} and Tsai, \{Ya Ru\} and Wang, \{Yun Ming\} and Shih, \{Shin Ru\} and Hsu, \{John Tsu An\}",

year = "2021",

month = jan,

doi = "10.1128/AAC.00695-20",

language = "英语",

volume = "65",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

TY - JOUR

T1 - Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

AU - Wang, Hsiang Ching

AU - Huang, Peng Nien

AU - Hung, Hui Chen

AU - Tseng, Sung Nien

AU - Chang, Chia Chia

AU - Tsai, Ya Ru

AU - Wang, Yun Ming

AU - Shih, Shin Ru

AU - Hsu, John Tsu An

PY - 2021/1

Y1 - 2021/1

N2 - We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

AB - We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

KW - Antiviral research

KW - Decoy receptor

KW - Enterovirus A71

KW - Neuropilin 1

KW - Virus receptor trap

UR - https://www.scopus.com/pages/publications/85098637216

U2 - 10.1128/AAC.00695-20

DO - 10.1128/AAC.00695-20

M3 - 文章

C2 - 33139286

AN - SCOPUS:85098637216

SN - 0066-4804

VL - 65

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

M1 - e00695-20

ER -

Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this