Effect of a poli poprot EI N B 3' hypervariable repeat genotype on plasma lipid concentration

J. H. Wu*, M. S. Chern, S. K. Lo, M. S. Wen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


The 3' hypervariable adenine and thymine rich repeat sequence of apolipoprotein B exhibited many length polymorphisms in general population. In a survey of 477 individuals, 18 alleles with repeat number ranged from 25 to 60 were found. Each repeat has an average of 15 base pair nucleotide sequence. A total of 45 genotypes was observed and 59% of the screened individuals were heterozygous. The majority subjects exhibited 35 repeat. Blood lipid level was compared between the homozygous 35 repeat individuals and other homozygous genotype or 35 repeat hétérozygote. Person with homozygous 33 repeat showed the highest total cholesterol, low-density lipoprotein cholesterol, ApoB concentration. The 55/35 subjects showed the highest lipoprotein (a) level. High triglycéride level was observed in 33/35 individuals. The lowest lipid levels were seen in 37/37 subjects. In general, repeats 37, 39, 45 and 47 were associated with low lipid level; repeats 33 and 55 were associated with high lipid level. Co-dominant allelic effect can be seen in 33/37 genotype. Paradoxically, coronary artery disease patients were found most frequently associated with 37/37 genotype. We found linkage disequilibrium between !he 43, 45, 47 repeats and apoB Ala591, 49, 51, 53, 55, 58, 60 repeats and apoB Lys4154 polymorphism. The 43-47 repeats have the same DNA sequence pattern that varies at the 5' end and the sub-terminus and the 49-58 repeats have the same variation pattern at the 5' end of the repeat region.

Original languageEnglish
Pages (from-to)A344
JournalFASEB Journal
Issue number3
StatePublished - 1996
Externally publishedYes


Dive into the research topics of 'Effect of a poli poprot EI N B 3' hypervariable repeat genotype on plasma lipid concentration'. Together they form a unique fingerprint.

Cite this