Effect of His Bundle Pacing on Abnormal Myocardial Fatty Acid and Glucose Metabolism Induced by Right Ventricular Pacing

Yu Sheng Lin, Huang Chung Chen, Wei Chieh Lee, Wan Chun Ho, Shun Fu Chang, Yung Lung Chen, Teng Yao Yang, Mien Cheng Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


BACKGROUND: Metabolic disorder is noted for pacing-induced cardiomyopathy. The benefits of His bundle pacing over right ventricular (RV) pacing in preventing pacing-induced cardiomyopathy from a metabolic perspective are yet to be fully understood. METHOD AND RESULTS: Three pig groups were established for this study: sham control, RV pacing (RV pacing for 6 months), and His pacing (RV pacing for 6 months, followed by His bundle pacing for 3 months). Complete atrioventricular block was created in the last 2 groups. Left ventricular function and dyssynchrony were assessed via echocardiography, while proteins linked to metabolism, endoplasmic reticulum stress, and inflammation in left ventricular myocardium were examined. The RV pacing group had significantly more left ventricular mechanical dyssynchrony compared with the other groups. The RV pacing group exhibited triglyceride and diacylglycerol accumulation in cardiomyocytes and higher expression of binding im-munoglobulin protein and tumor necrosis factor-α than the other groups. Additionally, the expression of CD36 was activated, while the expression of hormone-sensitive lipase was downregulated in the RV pacing group compared with the His pacing and sham control groups. Furthermore, the expressions of GLUT4 and pyruvate dehydrogenase were higher in the RV pacing group than the sham control and His pacing groups. Notably, the abnormal fatty acid and glucose metabolic pathways in the left ventricular myocardium during RV pacing could be corrected by His bundle pacing. CONCLUSIONS: His bundle pacing can mitigate the abnormal metabolism disorders, endoplasmic reticulum stress, and inflammation induced during RV pacing and may contribute to the superiority of conduction system pacing over RV pacing in reduc-ing heart failure hospitalization.

Original languageEnglish
Article numbere032386
Pages (from-to)e032386
JournalJournal of the American Heart Association
Issue number4
StatePublished - 20 02 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors.


  • cardiomyopathy
  • fatty acid metabolism
  • glucose metabolism
  • heart failure
  • His bundle pacing
  • right ventricular pacing
  • Bundle of His
  • Inflammation
  • Glucose
  • Heart Ventricles
  • Animals
  • Swine
  • Cardiac Pacing, Artificial/methods
  • Myocardium
  • Electrocardiography
  • Cardiomyopathies


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