Effect of low intensity ultrasound on the differentiation of liver cancer stem-like cells

I. Chi Lee, Siaka Fadera, Hao Li Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Statement of Purpose: Cancer stem cells (CSC) are a sub-population of cells and are recently proposed to be the cancer initiating cells responsible for tumor formation, recurrence, metastasis and contribute to cancer resistance. Chemotherapeutic drugs are mostly effective on normal cancer cells leaving CSCs mostly unaffected after treatment. Their quiescence nature makes them prime suspects to be responsible for resistance to anti-proliferative chemotherapy. Our previous study has used hyaluronic acid (HA) based multilayer film system to select liver cancer stem cell colonies. Several studies have demonstrated that low intensity ultrasound can induce stem cell differentiation and also can improve the anti-cancer activity of chemotherapeutic drugs. The goal of this study is to facilitate possibility of differentiation therapy of liver CSCs by using low intensity ultrasound.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages646
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 03 04 201906 04 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period03/04/1906/04/19

Bibliographical note

Publisher Copyright:
© 2019 Omnipress - All rights reserved.

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