Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese

Lung An Hsu; Yu Lin Ko; Ming Sheng Teng; Semon Wu; Hsin Hua Chou; Pi Yueh Chang; Hsien Hsun Chang

doi:10.1016/j.cca.2010.12.027

Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese

Lung An Hsu, Yu Lin Ko^*, Ming Sheng Teng, Semon Wu, Hsin Hua Chou, Pi Yueh Chang, Hsien Hsun Chang

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Background: The level of C-reactive protein (CRP), an inflammatory biomarker that predicts future cardiovascular events, is a heritable trait that has been associated with variants of CRP and hepatic nuclear factor-1α (HNF1A) genes. Our aim was to test the statistical association between HNF1A genotypes/haplotypes and serum CRP level in Taiwanese. Methods: A sample population of 617 Taiwanese subjects (all Han-Chinese origin) was enrolled. Five HNF1A single nucleotide polymorphisms (SNPs) rs1920792, rs1169288, rs7310409, rs2464196, rs1169310 were genotyped and analyzed. Results: After adjusting for clinical covariates, minor alleles of all the 5 study SNPs were associated with decreased CRP level (P= 0.0078, P=0.0107, P=0.0006, P=0.0004 and P=0.0003, respectively). A common haplotype (TGATA) tagged by the minor alleles of study SNPs was associated with significantly decreased CRP level (P= 0.0112). Subgroup analysis revealed that the association between HNF1A genotypes and CRP level occurred only in non-obese subjects. Conclusions: HNF1A polymorphisms are independently associated with CRP level in Taiwanese. Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals.

Original language	English
Pages (from-to)	725-729
Number of pages	5
Journal	Clinica Chimica Acta
Volume	412
Issue number	9-10
DOIs	https://doi.org/10.1016/j.cca.2010.12.027
State	Published - 11 04 2011

Keywords

C-reactive protein
Hepatic nuclear factor-1α
Obesity
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cca.2010.12.027

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@article{ec9a42ec7bfb4c80b5b104e588905061,

title = "Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese",

abstract = "Background: The level of C-reactive protein (CRP), an inflammatory biomarker that predicts future cardiovascular events, is a heritable trait that has been associated with variants of CRP and hepatic nuclear factor-1α (HNF1A) genes. Our aim was to test the statistical association between HNF1A genotypes/haplotypes and serum CRP level in Taiwanese. Methods: A sample population of 617 Taiwanese subjects (all Han-Chinese origin) was enrolled. Five HNF1A single nucleotide polymorphisms (SNPs) rs1920792, rs1169288, rs7310409, rs2464196, rs1169310 were genotyped and analyzed. Results: After adjusting for clinical covariates, minor alleles of all the 5 study SNPs were associated with decreased CRP level (P= 0.0078, P=0.0107, P=0.0006, P=0.0004 and P=0.0003, respectively). A common haplotype (TGATA) tagged by the minor alleles of study SNPs was associated with significantly decreased CRP level (P= 0.0112). Subgroup analysis revealed that the association between HNF1A genotypes and CRP level occurred only in non-obese subjects. Conclusions: HNF1A polymorphisms are independently associated with CRP level in Taiwanese. Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals.",

keywords = "C-reactive protein, Hepatic nuclear factor-1α, Obesity, Polymorphism",

author = "Hsu, {Lung An} and Ko, {Yu Lin} and Teng, {Ming Sheng} and Semon Wu and Chou, {Hsin Hua} and Chang, {Pi Yueh} and Chang, {Hsien Hsun}",

year = "2011",

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doi = "10.1016/j.cca.2010.12.027",

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volume = "412",

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journal = "Clinica Chimica Acta",

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TY - JOUR

T1 - Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese

AU - Hsu, Lung An

AU - Ko, Yu Lin

AU - Teng, Ming Sheng

AU - Wu, Semon

AU - Chou, Hsin Hua

AU - Chang, Pi Yueh

AU - Chang, Hsien Hsun

PY - 2011/4/11

Y1 - 2011/4/11

N2 - Background: The level of C-reactive protein (CRP), an inflammatory biomarker that predicts future cardiovascular events, is a heritable trait that has been associated with variants of CRP and hepatic nuclear factor-1α (HNF1A) genes. Our aim was to test the statistical association between HNF1A genotypes/haplotypes and serum CRP level in Taiwanese. Methods: A sample population of 617 Taiwanese subjects (all Han-Chinese origin) was enrolled. Five HNF1A single nucleotide polymorphisms (SNPs) rs1920792, rs1169288, rs7310409, rs2464196, rs1169310 were genotyped and analyzed. Results: After adjusting for clinical covariates, minor alleles of all the 5 study SNPs were associated with decreased CRP level (P= 0.0078, P=0.0107, P=0.0006, P=0.0004 and P=0.0003, respectively). A common haplotype (TGATA) tagged by the minor alleles of study SNPs was associated with significantly decreased CRP level (P= 0.0112). Subgroup analysis revealed that the association between HNF1A genotypes and CRP level occurred only in non-obese subjects. Conclusions: HNF1A polymorphisms are independently associated with CRP level in Taiwanese. Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals.

AB - Background: The level of C-reactive protein (CRP), an inflammatory biomarker that predicts future cardiovascular events, is a heritable trait that has been associated with variants of CRP and hepatic nuclear factor-1α (HNF1A) genes. Our aim was to test the statistical association between HNF1A genotypes/haplotypes and serum CRP level in Taiwanese. Methods: A sample population of 617 Taiwanese subjects (all Han-Chinese origin) was enrolled. Five HNF1A single nucleotide polymorphisms (SNPs) rs1920792, rs1169288, rs7310409, rs2464196, rs1169310 were genotyped and analyzed. Results: After adjusting for clinical covariates, minor alleles of all the 5 study SNPs were associated with decreased CRP level (P= 0.0078, P=0.0107, P=0.0006, P=0.0004 and P=0.0003, respectively). A common haplotype (TGATA) tagged by the minor alleles of study SNPs was associated with significantly decreased CRP level (P= 0.0112). Subgroup analysis revealed that the association between HNF1A genotypes and CRP level occurred only in non-obese subjects. Conclusions: HNF1A polymorphisms are independently associated with CRP level in Taiwanese. Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals.

KW - C-reactive protein

KW - Hepatic nuclear factor-1α

KW - Obesity

KW - Polymorphism

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SP - 725

EP - 729

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 9-10

ER -

Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese

Abstract

Keywords

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