Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: A pilot study

Kang Hsi Wu, Tefu Weng, Han Ping Wu, Ching Tien Peng, Ji Nan Sheu, Yu Hua Chao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).

Original languageEnglish
Pages (from-to)1193-1195
Number of pages3
JournalPediatric Infectious Disease Journal
Volume33
Issue number11
DOIs
StatePublished - 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2014 by Lippincott Williams & Wilkins.

Keywords

  • BK virus
  • Hematopoietic stem cell transplantation
  • Hemorrhagic cystitis
  • Lefunomide
  • Pediatrics

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