Abstract
Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).
Original language | English |
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Pages (from-to) | 1193-1195 |
Number of pages | 3 |
Journal | Pediatric Infectious Disease Journal |
Volume | 33 |
Issue number | 11 |
DOIs | |
State | Published - 2014 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:Copyright © 2014 by Lippincott Williams & Wilkins.
Keywords
- BK virus
- Hematopoietic stem cell transplantation
- Hemorrhagic cystitis
- Lefunomide
- Pediatrics