Effects of Agaricus blazei murill extract on immune responses in normal BALB/c mice

Nou Ying Tang, Jai Sing Yang, Jing Pin Lin, Te Chun Hsia, Ming Jen Fan, Jen Jyh Lin, Shu Wen Weng, Yi Shih Ma, Hsu Feng Lu, Jiann Jong Shen, Jaung Geng Lin*, Jing Gung Chung

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations


Agaricus blazei Murill (ABM) has shown particularly strong results in treating and preventing cancer and has also traditionally been used as a food source in Brazil. However, the exact immune responses regarding the phagocytosis of macrophage and, the activity of natural killer (NK) cells in normal mice after exposure to ABM extract was unclear. The goal of this study was to investigate whether or not ABM extract can promote immune responses in normal BALBIc mice. BALB/c mice were treated with different doses of ABM extract for different time periods. The results indicated that ABM extract significantly promoted the proliferation of splenocytes both in vitro and in vivo. ABM extract promoted the levels of interleukein-6 (IL-6) and, interferon-γ (IFN-γ) but reduced the levels of IL-4 in vitro and in vivo. The percentage of macrophages with phagocytosis after ABM extract treatment increased and these effects were of dose-dependent manners, both in vitro and in vivo. YAC-1 target cells were killed by NK cells from the mice after treatment with ABM extract at 3 and 6 mg/kg/day for up to 14 days at target cell ratios of 25:1 and 50:1. Taken together, these results show that ABM extract promoted immunomodulations in normal BALB/c mice in vitro and in vivo.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalIn Vivo
Issue number5
StatePublished - 2009


  • Agaricus blazei Murill extract
  • BALB/c mice
  • Immune responses
  • NK cells
  • Phagocytosis
  • YAC-1 target cells


Dive into the research topics of 'Effects of Agaricus blazei murill extract on immune responses in normal BALB/c mice'. Together they form a unique fingerprint.

Cite this