TY - JOUR
T1 - Effects of aging on pain responses and analgesic efficacy of morphine and clonidine in rats
AU - Chan, Samuel H.H.
AU - Lai, Yuan Yang
PY - 1982/1
Y1 - 1982/1
N2 - Changes in pain response and the analgesic efficacy of morphine and clonidine during senescence were studied in three groups of rats with different ages (54.4 ± 1.2, 162.2 ± 3.7, and 327.8 ± 1.7 days, mean ± se), using the hot plate assay as the nociceptive test. We found a progressive decrease in the hot plate latency, and a gradual reduction in the analgesic potency of morphine and clonidine in aging rats. We speculate that such changes were related to a decline in the content of catecholamines and acetylcholine, as well as a decrease in concentrations of dopamine, acetylcholine, and opiate receptors in the aging brain. These results have implications for the role of the medullary nucleus reticularis gigantocellularis as a common neural substrate for pain suppression and analgesia promoted by morphine and clonidine.
AB - Changes in pain response and the analgesic efficacy of morphine and clonidine during senescence were studied in three groups of rats with different ages (54.4 ± 1.2, 162.2 ± 3.7, and 327.8 ± 1.7 days, mean ± se), using the hot plate assay as the nociceptive test. We found a progressive decrease in the hot plate latency, and a gradual reduction in the analgesic potency of morphine and clonidine in aging rats. We speculate that such changes were related to a decline in the content of catecholamines and acetylcholine, as well as a decrease in concentrations of dopamine, acetylcholine, and opiate receptors in the aging brain. These results have implications for the role of the medullary nucleus reticularis gigantocellularis as a common neural substrate for pain suppression and analgesia promoted by morphine and clonidine.
UR - http://www.scopus.com/inward/record.url?scp=0020039199&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(82)90011-5
DO - 10.1016/0014-4886(82)90011-5
M3 - 文章
C2 - 7060671
AN - SCOPUS:0020039199
SN - 0014-4886
VL - 75
SP - 112
EP - 119
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -