Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL

Yi Jiun Su; Anne Marijn Kramer; Mark P. Hamilton; Neha Agarwal; Hrishikesh K. Srinagesh; John H. Baird; Bita Sahaf; Adam Kuo; Zachary J. Ehlinger; Moksha H. Desai; Skyler P. Rietberg; Ramya Tunuguntla; Shabnum Patel; Harshini Chinnasamy; Nikolaos Gkitsas-Long; Dorota D. Klysz; Annie Kathleen Brown; Sushma Bharadwaj; Saurabh Dahiya; Melody Smith; Lori Muffly; Crystal L. Mackall; Zinaida Good; Steven A. Feldman; David B. Miklos; Matthew J. Frank

doi:10.1158/2159-8290.CD-24-1071

Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL

Yi Jiun Su
, Anne Marijn Kramer
, Mark P. Hamilton
, Neha Agarwal
, Hrishikesh K. Srinagesh
, John H. Baird
, Bita Sahaf
, Adam Kuo
, Zachary J. Ehlinger
, Moksha H. Desai
, Skyler P. Rietberg
, Ramya Tunuguntla
, Shabnum Patel
, Harshini Chinnasamy
, Nikolaos Gkitsas-Long
, Dorota D. Klysz
, Annie Kathleen Brown
, Sushma Bharadwaj
, Saurabh Dahiya
, Melody Smith

Lori Muffly, Crystal L. Mackall, Zinaida Good, Steven A. Feldman, David B. Miklos, Matthew J. Frank^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Late leukapheresis (>6 months after CAR19) resulted in less residual CAR19, higher CAR22 CD4+ naïve T and TCM cells, less TEM cells, and higher CD8+ TCM cells, but similar clinical outcomes to those with early leukapheresis. CAR22 responses were associated with higher transduction efficiency and CD8+ TCM and less CD8+ TEM cells.

Original language	English
Pages (from-to)	733-747
Number of pages	15
Journal	Cancer Discovery
Volume	15
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-24-1071
State	Published - 02 04 2025
Externally published	Yes

Bibliographical note

Keywords

Humans
Immunotherapy, Adoptive/methods
Antigens, CD19/immunology
Receptors, Chimeric Antigen/immunology
Sialic Acid Binding Ig-like Lectin 2/immunology
Male
Treatment Outcome
Female
Middle Aged
Receptors, Antigen, T-Cell
Leukemia, Lymphocytic, Chronic, B-Cell/therapy
Aged
Leukapheresis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/2159-8290.CD-24-1071

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Su, Y. J., Kramer, A. M., Hamilton, M. P., Agarwal, N., Srinagesh, H. K., Baird, J. H., Sahaf, B., Kuo, A., Ehlinger, Z. J., Desai, M. H., Rietberg, S. P., Tunuguntla, R., Patel, S., Chinnasamy, H., Gkitsas-Long, N., Klysz, D. D., Brown, A. K., Bharadwaj, S., Dahiya, S., ... Frank, M. J. (2025). Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL. Cancer Discovery, 15(4), 733-747. https://doi.org/10.1158/2159-8290.CD-24-1071

@article{140cd351b554496eb1b4c96a84722b2a,

title = "Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL",

abstract = "Late leukapheresis (>6 months after CAR19) resulted in less residual CAR19, higher CAR22 CD4+ na{\"i}ve T and TCM cells, less TEM cells, and higher CD8+ TCM cells, but similar clinical outcomes to those with early leukapheresis. CAR22 responses were associated with higher transduction efficiency and CD8+ TCM and less CD8+ TEM cells.",

keywords = "Humans, Immunotherapy, Adoptive/methods, Antigens, CD19/immunology, Receptors, Chimeric Antigen/immunology, Sialic Acid Binding Ig-like Lectin 2/immunology, Male, Treatment Outcome, Female, Middle Aged, Receptors, Antigen, T-Cell, Leukemia, Lymphocytic, Chronic, B-Cell/therapy, Aged, Leukapheresis",

author = "Su, \{Yi Jiun\} and Kramer, \{Anne Marijn\} and Hamilton, \{Mark P.\} and Neha Agarwal and Srinagesh, \{Hrishikesh K.\} and Baird, \{John H.\} and Bita Sahaf and Adam Kuo and Ehlinger, \{Zachary J.\} and Desai, \{Moksha H.\} and Rietberg, \{Skyler P.\} and Ramya Tunuguntla and Shabnum Patel and Harshini Chinnasamy and Nikolaos Gkitsas-Long and Klysz, \{Dorota D.\} and Brown, \{Annie Kathleen\} and Sushma Bharadwaj and Saurabh Dahiya and Melody Smith and Lori Muffly and Mackall, \{Crystal L.\} and Zinaida Good and Feldman, \{Steven A.\} and Miklos, \{David B.\} and Frank, \{Matthew J.\}",

note = "{\textcopyright}2025 American Association for Cancer Research.",

year = "2025",

month = apr,

day = "2",

doi = "10.1158/2159-8290.CD-24-1071",

language = "英语",

volume = "15",

pages = "733--747",

journal = "Cancer Discovery",

issn = "2159-8274",

publisher = "American Association for Cancer Research Inc.",

number = "4",

}

Su, YJ, Kramer, AM, Hamilton, MP, Agarwal, N, Srinagesh, HK, Baird, JH, Sahaf, B, Kuo, A, Ehlinger, ZJ, Desai, MH, Rietberg, SP, Tunuguntla, R, Patel, S, Chinnasamy, H, Gkitsas-Long, N, Klysz, DD, Brown, AK, Bharadwaj, S, Dahiya, S, Smith, M, Muffly, L, Mackall, CL, Good, Z, Feldman, SA, Miklos, DB & Frank, MJ 2025, 'Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL', Cancer Discovery, vol. 15, no. 4, pp. 733-747. https://doi.org/10.1158/2159-8290.CD-24-1071

TY - JOUR

T1 - Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL

AU - Su, Yi Jiun

AU - Kramer, Anne Marijn

AU - Hamilton, Mark P.

AU - Agarwal, Neha

AU - Srinagesh, Hrishikesh K.

AU - Baird, John H.

AU - Sahaf, Bita

AU - Kuo, Adam

AU - Ehlinger, Zachary J.

AU - Desai, Moksha H.

AU - Rietberg, Skyler P.

AU - Tunuguntla, Ramya

AU - Patel, Shabnum

AU - Chinnasamy, Harshini

AU - Gkitsas-Long, Nikolaos

AU - Klysz, Dorota D.

AU - Brown, Annie Kathleen

AU - Bharadwaj, Sushma

AU - Dahiya, Saurabh

AU - Smith, Melody

AU - Muffly, Lori

AU - Mackall, Crystal L.

AU - Good, Zinaida

AU - Feldman, Steven A.

AU - Miklos, David B.

AU - Frank, Matthew J.

PY - 2025/4/2

Y1 - 2025/4/2

N2 - Late leukapheresis (>6 months after CAR19) resulted in less residual CAR19, higher CAR22 CD4+ naïve T and TCM cells, less TEM cells, and higher CD8+ TCM cells, but similar clinical outcomes to those with early leukapheresis. CAR22 responses were associated with higher transduction efficiency and CD8+ TCM and less CD8+ TEM cells.

AB - Late leukapheresis (>6 months after CAR19) resulted in less residual CAR19, higher CAR22 CD4+ naïve T and TCM cells, less TEM cells, and higher CD8+ TCM cells, but similar clinical outcomes to those with early leukapheresis. CAR22 responses were associated with higher transduction efficiency and CD8+ TCM and less CD8+ TEM cells.

KW - Humans

KW - Immunotherapy, Adoptive/methods

KW - Antigens, CD19/immunology

KW - Receptors, Chimeric Antigen/immunology

KW - Sialic Acid Binding Ig-like Lectin 2/immunology

KW - Male

KW - Treatment Outcome

KW - Female

KW - Middle Aged

KW - Receptors, Antigen, T-Cell

KW - Leukemia, Lymphocytic, Chronic, B-Cell/therapy

KW - Aged

KW - Leukapheresis

UR - https://www.scopus.com/pages/publications/105002790817

U2 - 10.1158/2159-8290.CD-24-1071

DO - 10.1158/2159-8290.CD-24-1071

M3 - 文章

C2 - 39775812

AN - SCOPUS:105002790817

SN - 2159-8274

VL - 15

SP - 733

EP - 747

JO - Cancer Discovery

JF - Cancer Discovery

IS - 4

ER -

Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL

Abstract

Bibliographical note

Keywords

UN SDGs

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