Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

Tang Her Jaing; Shih Hsiang Chen; Yu Chuan Wen; Tsung Yen Chang; Ya Chun Yang; Pei Kwei Tsay

doi:10.1177/0963689717753187

Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

Tang Her Jaing^*, Shih Hsiang Chen, Yu Chuan Wen, Tsung Yen Chang, Ya Chun Yang, Pei Kwei Tsay

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability (P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.

Original language	English
Pages (from-to)	515-519
Number of pages	5
Journal	Cell Transplantation
Volume	27
Issue number	3
DOIs	https://doi.org/10.1177/0963689717753187
State	Published - 01 03 2018

Bibliographical note

Publisher Copyright:
© 2018, The Author(s) 2018.

Keywords

cryopreservation
transplantation
umbilical cord blood

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10.1177/0963689717753187

Cite this

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title = "Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation",

abstract = "Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48\%). There was no significant association between cryopreservation duration and neutrophil engraftment probability (P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.",

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author = "Jaing, \{Tang Her\} and Chen, \{Shih Hsiang\} and Wen, \{Yu Chuan\} and Chang, \{Tsung Yen\} and Yang, \{Ya Chun\} and Tsay, \{Pei Kwei\}",

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year = "2018",

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doi = "10.1177/0963689717753187",

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T1 - Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

AU - Jaing, Tang Her

AU - Chen, Shih Hsiang

AU - Wen, Yu Chuan

AU - Chang, Tsung Yen

AU - Yang, Ya Chun

AU - Tsay, Pei Kwei

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability (P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.

AB - Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability (P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.

KW - cryopreservation

KW - transplantation

KW - umbilical cord blood

UR - https://www.scopus.com/pages/publications/85048286305

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DO - 10.1177/0963689717753187

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SN - 0963-6897

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EP - 519

JO - Cell Transplantation

JF - Cell Transplantation

IS - 3

ER -

Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

Abstract

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Keywords

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