Effects of early life stress on neuroendocrine and neurobehavior: Mechanisms and implications

Ming Chi Lai, Li Tung Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Evidence continues to mount that adverse experiences early in life have an impact on brain functions. Early life stress can program the development of the hypothalamic-pituitary-adrenal axis and cause alterations of neurochemistry and signaling pathways involved in regulating neuroplasticity, with resultant neurobehavioral changes. Early life experiences and genetic factors appear to interact in determining the individual vulnerability to mental health disorders. We reviewed the effects of early life stress on neuroendocrine regulation and the relevance to neurobehavioral development.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalPediatrics and Neonatology
Volume52
Issue number3
DOIs
StatePublished - 06 2011

Keywords

  • early life stress
  • epileptogenesis
  • hypothalamic-pituitary-adrenal axis
  • learning and memory
  • psychiatric disorders

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