Effects of external magnetic field on biodistribution of nanoparticles: A histological study

Tony Wu; Mu Yi Hua; Jyh ping Chen; Kuo Chen Wei; Shih Ming Jung; Yeu Jhy Chang; Mei Jie Jou; Yunn Hwa Ma

doi:10.1016/j.jmmm.2006.10.1202

Effects of external magnetic field on biodistribution of nanoparticles: A histological study

Tony Wu, Mu Yi Hua, Jyh ping Chen, Kuo Chen Wei, Shih Ming Jung, Yeu Jhy Chang, Mei Jie Jou, Yunn Hwa Ma^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

23 Scopus citations

Abstract

This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe₃O₄ NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP.

Original language	English
Pages (from-to)	372-375
Number of pages	4
Journal	Journal of Magnetism and Magnetic Materials
Volume	311
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jmmm.2006.10.1202
State	Published - 04 2007

Keywords

Biodistribution
External magnetic field
Histology
Nanoparticle
Prussian blue stain

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10.1016/j.jmmm.2006.10.1202

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title = "Effects of external magnetic field on biodistribution of nanoparticles: A histological study",

abstract = "This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP.",

keywords = "Biodistribution, External magnetic field, Histology, Nanoparticle, Prussian blue stain",

author = "Tony Wu and Hua, \{Mu Yi\} and Chen, \{Jyh ping\} and Wei, \{Kuo Chen\} and Jung, \{Shih Ming\} and Chang, \{Yeu Jhy\} and Jou, \{Mei Jie\} and Ma, \{Yunn Hwa\}",

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TY - JOUR

T1 - Effects of external magnetic field on biodistribution of nanoparticles

T2 - A histological study

AU - Wu, Tony

AU - Hua, Mu Yi

AU - Chen, Jyh ping

AU - Wei, Kuo Chen

AU - Jung, Shih Ming

AU - Chang, Yeu Jhy

AU - Jou, Mei Jie

AU - Ma, Yunn Hwa

PY - 2007/4

Y1 - 2007/4

N2 - This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP.

AB - This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP.

KW - Biodistribution

KW - External magnetic field

KW - Histology

KW - Nanoparticle

KW - Prussian blue stain

UR - https://www.scopus.com/pages/publications/33947182919

U2 - 10.1016/j.jmmm.2006.10.1202

DO - 10.1016/j.jmmm.2006.10.1202

M3 - 文章

AN - SCOPUS:33947182919

SN - 0304-8853

VL - 311

SP - 372

EP - 375

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1 SPEC. ISS.

ER -

Effects of external magnetic field on biodistribution of nanoparticles: A histological study

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Keywords

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