Effects of Genital Nerve Stimulation Amplitude on Bladder Capacity in Spinal Cord Injured Subjects

Shauh Der Yeh, Bor Shing Lin, Shih Ching Chen, Chih Hwa Chen, Kenneth J. Gustafson, Dennis J. Bourbeau, Chellappan Praveen Rajneesh, Chih Wei Peng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations


Background/Purpose. Few studies have investigated the effects of changing the amplitude of dorsal genital nerve stimulation (GNS) on the inhibition of neurogenic detrusor overactivity in individuals with spinal cord injury (SCI). The present study determined the acute effects of changes in GNS amplitude on bladder capacity gain in individuals with SCI and neurogenic detrusor overactivity. Methods. Cystometry was used to assess the effects of continuous GNS on bladder capacity during bladder filling. The cystometric trials were conducted in a randomized sequence of cystometric fills with continuous GNS at stimulation amplitudes ranging from 1 to 4 times of threshold (T) required to elicit the genitoanal reflex. Results. The bladder capacity increased minimally and maximally by approximately 34% and 77%, respectively, of the baseline bladder capacity at 1.5 T and 3.2 T, respectively. Stimulation amplitude and bladder capacity were significantly correlated (R = 0.55, P = 0.01). Conclusion. This study demonstrates a linear correlation between the stimulation amplitude ranging from 1 to 4T and bladder capacity gain in individuals with SCI in acute GNS experiments. However, GNS amplitude out of the range of 1-4T might not be exactly a linear relationship due to subthreshold or saturation factors. Thus, further research is needed to examine this issue. Nevertheless, these results may be critical in laying the groundwork for understanding the effectiveness of acute GNS in the treatment of neurogenic detrusor overactivity.

Original languageEnglish
Article number1248342
JournalEvidence-based Complementary and Alternative Medicine
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Shauh-Der Yeh et al.


Dive into the research topics of 'Effects of Genital Nerve Stimulation Amplitude on Bladder Capacity in Spinal Cord Injured Subjects'. Together they form a unique fingerprint.

Cite this