Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV

Huey Ling Chen; Lung Huang Lin; Fu Chang Hu; Jian Te Lee; Wen Terng Lin; Yao Jung Yang; Fu Chen Huang; Shu Fen Wu; Solomon Chih Cheng Chen; Wan Hsin Wen; Chia Hsiang Chu; Yen Hsuan Ni; Hongyuan Hsu; Pei Lin Tsai; Cheng Lun Chiang; Ming Kwang Shyu; Ping Ing Lee; Feng Yee Chang; Mei Hwei Chang

doi:10.1053/j.gastro.2011.12.035

Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV

Huey Ling Chen, Lung Huang Lin, Fu Chang Hu, Jian Te Lee, Wen Terng Lin, Yao Jung Yang, Fu Chen Huang, Shu Fen Wu, Solomon Chih Cheng Chen, Wan Hsin Wen, Chia Hsiang Chu, Yen Hsuan Ni, Hongyuan Hsu, Pei Lin Tsai, Cheng Lun Chiang, Ming Kwang Shyu, Ping Ing Lee, Feng Yee Chang, Mei Hwei Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

228 Scopus citations

Abstract

Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV.

Original language	English
Pages (from-to)	773-781.e2
Journal	Gastroenterology
Volume	142
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2011.12.035
State	Published - 04 2012
Externally published	Yes

Keywords

HBsAg Carrier
Pediatric Liver Disease
Screening Pregnant Women
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.gastro.2011.12.035

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Chen, H. L., Lin, L. H., Hu, F. C., Lee, J. T., Lin, W. T., Yang, Y. J., Huang, F. C., Wu, S. F., Chen, S. C. C., Wen, W. H., Chu, C. H., Ni, Y. H., Hsu, H., Tsai, P. L., Chiang, C. L., Shyu, M. K., Lee, P. I., Chang, F. Y., & Chang, M. H. (2012). Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV. Gastroenterology, 142(4), 773-781.e2. https://doi.org/10.1053/j.gastro.2011.12.035

@article{5e13775845dd42f692b10d76b602b055,

title = "Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV",

abstract = "Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV.",

keywords = "HBsAg Carrier, Pediatric Liver Disease, Screening Pregnant Women, Vaccination",

author = "Chen, {Huey Ling} and Lin, {Lung Huang} and Hu, {Fu Chang} and Lee, {Jian Te} and Lin, {Wen Terng} and Yang, {Yao Jung} and Huang, {Fu Chen} and Wu, {Shu Fen} and Chen, {Solomon Chih Cheng} and Wen, {Wan Hsin} and Chu, {Chia Hsiang} and Ni, {Yen Hsuan} and Hongyuan Hsu and Tsai, {Pei Lin} and Chiang, {Cheng Lun} and Shyu, {Ming Kwang} and Lee, {Ping Ing} and Chang, {Feng Yee} and Chang, {Mei Hwei}",

year = "2012",

month = apr,

doi = "10.1053/j.gastro.2011.12.035",

language = "英语",

volume = "142",

pages = "773--781.e2",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "4",

}

Chen, HL, Lin, LH, Hu, FC, Lee, JT, Lin, WT, Yang, YJ, Huang, FC, Wu, SF, Chen, SCC, Wen, WH, Chu, CH, Ni, YH, Hsu, H, Tsai, PL, Chiang, CL, Shyu, MK, Lee, PI, Chang, FY & Chang, MH 2012, 'Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV', Gastroenterology, vol. 142, no. 4, pp. 773-781.e2. https://doi.org/10.1053/j.gastro.2011.12.035

TY - JOUR

T1 - Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV

AU - Chen, Huey Ling

AU - Lin, Lung Huang

AU - Hu, Fu Chang

AU - Lee, Jian Te

AU - Lin, Wen Terng

AU - Yang, Yao Jung

AU - Huang, Fu Chen

AU - Wu, Shu Fen

AU - Chen, Solomon Chih Cheng

AU - Wen, Wan Hsin

AU - Chu, Chia Hsiang

AU - Ni, Yen Hsuan

AU - Hsu, Hongyuan

AU - Tsai, Pei Lin

AU - Chiang, Cheng Lun

AU - Shyu, Ming Kwang

AU - Lee, Ping Ing

AU - Chang, Feng Yee

AU - Chang, Mei Hwei

PY - 2012/4

Y1 - 2012/4

N2 - Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV.

AB - Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B immunoglobulin (HBIG) to newborns. We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission. Methods: We analyzed data from 2356 children born to HBsAg-positive mothers, identified through prenatal maternal screens. In addition to HBV vaccines, HBIG was given to all 583 children with hepatitis B e antigen (HBeAg)-positive mothers and to 723 of 1773 children with HBeAg-negative mothers. Serology tests for HBV were performed from 2007 to 2009, when children were 0.510 years old. Results: A significantly greater percentage of children with HBeAg-positive mothers tested positive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children with HBeAg-negative mothers (1.58% and 0.29%, respectively; P <.0001 and <.001). Among the HBV-infected children, the rate of chronicity also was higher among children with HBeAg-positive mothers than children with HBeAg-negative mothers (54% vs 17%; P =.002). Similar rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P =.19) and HBsAg (0.14% and 0.29%; P =.65) were noted in children born to HBeAg-negative mothers who were or were not given HBIG. Infantile fulminant hepatitis developed in 1 of 1050 children who did not receive HBIG (.095%). Conclusions: Children born to HBeAg-positive mothers are at greatest risk for chronic HBV infection (9.26%), despite immunization. Administration of HBIG to infants born to HBeAg-negative mothers did not appear to reduce the rate of chronic HBV infection, but might prevent infantile fulminant hepatitis. Screening pregnant women for HBsAg and HBeAg might control mother-to-infant transmission of HBV.

KW - HBsAg Carrier

KW - Pediatric Liver Disease

KW - Screening Pregnant Women

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=84859413328&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2011.12.035

DO - 10.1053/j.gastro.2011.12.035

M3 - 文章

AN - SCOPUS:84859413328

SN - 0016-5085

VL - 142

SP - 773-781.e2

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV

Abstract

Keywords

UN SDGs

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