Abstract
Previous work from our laboratory has indicated that ovine proclatin can produce a rapid stimulation (within 1 h) of dopamine release from nigrostriatal and mesolimbic dopaminergic neurons of male rats. In the present experiment we attempted to determine whether this effect of prolactin was a function of an increase in the activation of dopamine synthesis. To examine this possibility we used the drug NSD 1015. This drug is a decarboxylase inhibitor that leads to dopa accumulation and is used as an index of in vivo tyrosine hydroxylase activity. Our results demonstrated that ovine proclatin increased turnover of dopamine but had no effect upon tyrosine hydroxylase activation (up to 4 h) in both dorsal and ventral striatal dopaminergic neurons. In contrast, ovine prolacting had a clear effect (within 4 h) on tyrosine hydroxylase activity in mediobasal hypothalamic dopaminergic neurons. These results suggest that ovine prolactin can differentially alter synthesis/release processes of dopamine from these sites.
Original language | English |
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Pages (from-to) | 473-479 |
Number of pages | 7 |
Journal | European Journal of Pharmacology |
Volume | 166 |
Issue number | 3 |
DOIs | |
State | Published - 03 08 1989 |
Externally published | Yes |
Keywords
- 2,4-Dihydroxyphenylalanine (DOPA)
- 3,4-Dihydroxyphenylacetic acid (DOPAC), Striatum
- Nucleus accumbens
- Prolactin
- Tyrosine hydroxylase