Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao Chun Yang; Chin Han Wu; Tak Wah Wong; Feng Jie Lai; Kai Che Wei; Tzu Kai Lin; Chrang Shi Lin; Juemin Zhao; Leihong Xiang; Chao Hsing Kao; Ying Jan Wang; Cheng Che Eric Lan; Hamm Ming Sheu

doi:10.1111/1346-8138.15703

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao Chun Yang^*, Chin Han Wu, Tak Wah Wong, Feng Jie Lai, Kai Che Wei, Tzu Kai Lin, Chrang Shi Lin, Juemin Zhao, Leihong Xiang, Chao Hsing Kao, Ying Jan Wang, Cheng Che Eric Lan, Hamm Ming Sheu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

Original language	English
Pages (from-to)	344-352
Number of pages	9
Journal	Journal of Dermatology
Volume	48
Issue number	3
DOIs	https://doi.org/10.1111/1346-8138.15703
State	Published - 03 2021
Externally published	Yes

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Publisher Copyright:
© 2021 Japanese Dermatological Association

Keywords

Solanum undatum
actinic keratosis
photoaging
photocarcinogenesis
solamargine

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title = "Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis",

abstract = "SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.",

keywords = "Solanum undatum, actinic keratosis, photoaging, photocarcinogenesis, solamargine",

author = "Yang, {Chao Chun} and Wu, {Chin Han} and Wong, {Tak Wah} and Lai, {Feng Jie} and Wei, {Kai Che} and Lin, {Tzu Kai} and Lin, {Chrang Shi} and Juemin Zhao and Leihong Xiang and Kao, {Chao Hsing} and Wang, {Ying Jan} and Lan, {Cheng Che Eric} and Sheu, {Hamm Ming}",

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year = "2021",

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doi = "10.1111/1346-8138.15703",

language = "英语",

volume = "48",

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AU - Yang, Chao Chun

AU - Wu, Chin Han

AU - Wong, Tak Wah

AU - Lai, Feng Jie

AU - Wei, Kai Che

AU - Lin, Tzu Kai

AU - Lin, Chrang Shi

AU - Zhao, Juemin

AU - Xiang, Leihong

AU - Kao, Chao Hsing

AU - Wang, Ying Jan

AU - Lan, Cheng Che Eric

AU - Sheu, Hamm Ming

PY - 2021/3

Y1 - 2021/3

N2 - SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

AB - SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

KW - Solanum undatum

KW - actinic keratosis

KW - photoaging

KW - photocarcinogenesis

KW - solamargine

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ER -

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

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Keywords

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