Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao Chun Yang; Chin Han Wu; Tak Wah Wong; Feng Jie Lai; Kai Che Wei; Tzu Kai Lin; Chrang Shi Lin; Juemin Zhao; Leihong Xiang; Chao Hsing Kao; Ying Jan Wang; Cheng Che Eric Lan; Hamm Ming Sheu

doi:10.1111/1346-8138.15703

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao Chun Yang^*
, Chin Han Wu
, Tak Wah Wong
, Feng Jie Lai
, Kai Che Wei
, Tzu Kai Lin
, Chrang Shi Lin
, Juemin Zhao
, Leihong Xiang
, Chao Hsing Kao
, Ying Jan Wang
, Cheng Che Eric Lan
, Hamm Ming Sheu

^*Corresponding author for this work

School of Medicine

National Cheng Kung University
Shu-Zen Junior College of Medicine and Management
Chi-Mei Medical Center
Veterans General Hospital-Kaohsiung Taiwan
National Yang Ming Chiao Tung University
Fudan University
Kao Chao-Hsing Dermatologic Clinic
Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

Original language	English
Pages (from-to)	344-352
Number of pages	9
Journal	Journal of Dermatology
Volume	48
Issue number	3
DOIs	https://doi.org/10.1111/1346-8138.15703
State	Published - 03 2021

Bibliographical note

Publisher Copyright:
© 2021 Japanese Dermatological Association

Keywords

Solanum undatum
actinic keratosis
photoaging
photocarcinogenesis
solamargine

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10.1111/1346-8138.15703

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@article{c3cd6169378f41f099a68dd10285ad97,

title = "Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis",

abstract = "SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.",

keywords = "Solanum undatum, actinic keratosis, photoaging, photocarcinogenesis, solamargine",

author = "Yang, \{Chao Chun\} and Wu, \{Chin Han\} and Wong, \{Tak Wah\} and Lai, \{Feng Jie\} and Wei, \{Kai Che\} and Lin, \{Tzu Kai\} and Lin, \{Chrang Shi\} and Juemin Zhao and Leihong Xiang and Kao, \{Chao Hsing\} and Wang, \{Ying Jan\} and Lan, \{Cheng Che Eric\} and Sheu, \{Hamm Ming\}",

note = "Publisher Copyright: {\textcopyright} 2021 Japanese Dermatological Association",

year = "2021",

month = mar,

doi = "10.1111/1346-8138.15703",

language = "英语",

volume = "48",

pages = "344--352",

journal = "Journal of Dermatology",

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TY - JOUR

T1 - Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

AU - Yang, Chao Chun

AU - Wu, Chin Han

AU - Wong, Tak Wah

AU - Lai, Feng Jie

AU - Wei, Kai Che

AU - Lin, Tzu Kai

AU - Lin, Chrang Shi

AU - Zhao, Juemin

AU - Xiang, Leihong

AU - Kao, Chao Hsing

AU - Wang, Ying Jan

AU - Lan, Cheng Che Eric

AU - Sheu, Hamm Ming

PY - 2021/3

Y1 - 2021/3

N2 - SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

AB - SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

KW - Solanum undatum

KW - actinic keratosis

KW - photoaging

KW - photocarcinogenesis

KW - solamargine

UR - https://www.scopus.com/pages/publications/85099358774

U2 - 10.1111/1346-8138.15703

DO - 10.1111/1346-8138.15703

M3 - 文章

C2 - 33458860

AN - SCOPUS:85099358774

SN - 0385-2407

VL - 48

SP - 344

EP - 352

JO - Journal of Dermatology

JF - Journal of Dermatology

IS - 3

ER -

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Abstract

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Keywords

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