Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

Marion Man Ying Chan; Chi Tang Ho; Hsing I. Huang

doi:10.1016/0304-3835(95)03913-H

Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

Marion Man Ying Chan^*
, Chi Tang Ho
, Hsing I. Huang

^*Corresponding author for this work

Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Journal Article › peer-review

149 Scopus citations

Abstract

In chronic inflammation, cytokines induce the production of nitric oxide (NO^.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. The compounds epigallocatechin gallate (EGCG), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. They are known to be anti-inflammatory and cancer preventive. Therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. They inhibited lipopolysaccharide (LPS) and interferon-γ (IFNγ) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 μM. Cell viability assays verified that the inhibition was not due to general cellular toxicity.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Cancer Letters
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(95)03913-H
State	Published - 04 09 1995
Externally published	Yes

Keywords

Antioxidants
Carcinogenesis
Diet
Interferon-γ, Nitric oxide
Phytochemicals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(95)03913-H

Cite this

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title = "Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production",

abstract = "In chronic inflammation, cytokines induce the production of nitric oxide (NO.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. The compounds epigallocatechin gallate (EGCG), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. They are known to be anti-inflammatory and cancer preventive. Therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. They inhibited lipopolysaccharide (LPS) and interferon-γ (IFNγ) induced nitrite production by mouse peritoneal cells by more than 50\% at 2.5-10 μM. Cell viability assays verified that the inhibition was not due to general cellular toxicity.",

keywords = "Antioxidants, Carcinogenesis, Diet, Interferon-γ, Nitric oxide, Phytochemicals",

author = "Chan, \{Marion Man Ying\} and Ho, \{Chi Tang\} and Huang, \{Hsing I.\}",

year = "1995",

month = sep,

day = "4",

doi = "10.1016/0304-3835(95)03913-H",

language = "英语",

volume = "96",

pages = "23--29",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

AU - Chan, Marion Man Ying

AU - Ho, Chi Tang

AU - Huang, Hsing I.

PY - 1995/9/4

Y1 - 1995/9/4

N2 - In chronic inflammation, cytokines induce the production of nitric oxide (NO.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. The compounds epigallocatechin gallate (EGCG), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. They are known to be anti-inflammatory and cancer preventive. Therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. They inhibited lipopolysaccharide (LPS) and interferon-γ (IFNγ) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 μM. Cell viability assays verified that the inhibition was not due to general cellular toxicity.

AB - In chronic inflammation, cytokines induce the production of nitric oxide (NO.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. The compounds epigallocatechin gallate (EGCG), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. They are known to be anti-inflammatory and cancer preventive. Therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. They inhibited lipopolysaccharide (LPS) and interferon-γ (IFNγ) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 μM. Cell viability assays verified that the inhibition was not due to general cellular toxicity.

KW - Antioxidants

KW - Carcinogenesis

KW - Diet

KW - Interferon-γ, Nitric oxide

KW - Phytochemicals

UR - https://www.scopus.com/pages/publications/0029128319

U2 - 10.1016/0304-3835(95)03913-H

DO - 10.1016/0304-3835(95)03913-H

M3 - 文章

C2 - 7553604

AN - SCOPUS:0029128319

SN - 0304-3835

VL - 96

SP - 23

EP - 29

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

Abstract

Keywords

UN SDGs

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