Efficacy and safety of biodegradable collagen-glycosaminoglycan polymer as a material for scleral buckling

Wei Chi Wu, Chi-chung Lai, Henry Shen Lih Chen, Ming Hui Sun, Lien Min Lee, Chia Pang Shih, Howard Wen Hao Lee, Wei Cherng Hsu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations


PURPOSE. To test the efficacy and safety of a biodegradable collagen-glycosaminoglycan (CG) polymer as the material for scleral buckling in rabbit eyes. METHODS. Segmental scleral buckling was performed by using a silicone sponge in one eye and a biodegradable CG polymer in the other eye of 20 rabbits. Wound and conjunctival reactions were evaluated by external photographs 1 day and then every week after surgery. Echography was used to evaluate the extent of the buckling effect. Electroretinograms were used to evaluate the retinal function after scleral buckling. Histology and immunohistochemistry were used to check the tissue reaction and distribution of myofibroblasts during wound healing. Scanning electronic microscopy of buckling materials was used to analyze structural changes after episcleral implantation. RESULTS. Biodegradable collagen initially achieved a buckling effect comparable to a silicone sponge; the buckling effect decreased after 1 month. Within 8 to 12 weeks, the collagen was gradually absorbed. After implantation, the collagen matrix degraded, and the pore size decreased as a result of compression and degradation. In contrast, no major structural changes were observed in silicone sponges, except some cell debris, fibrin, and blood cells were detected inside the porous structure of the sponge. The inflammatory responses were comparable between sponge and collagen in most areas of peribuckling histology. In areas of degraded collagen, a foreign body reaction was observable. Electroretinography revealed no detectable difference in retinal function between control and experimental eyes. CONCLUSIONS. Biodegradable collagen was used effectively and safely as a material for scleral buckling.

Original languageEnglish
Pages (from-to)2673-2678
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number6
StatePublished - 06 2008


Dive into the research topics of 'Efficacy and safety of biodegradable collagen-glycosaminoglycan polymer as a material for scleral buckling'. Together they form a unique fingerprint.

Cite this