Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma

Kun Ming Chan, Ming Chin Yu, Ting Jung Wu, Chen Fang Lee, Tse Ching Chen, Wei Chen Lee*, Miin Fu Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

55 Scopus citations

Abstract

AIM: To clarify the benefit of surgical excision for patients with extrahepatic metastases of hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed the medical records of 140 patients with pathologically proven extrahepatic metastases of HCC and evaluated the outcomes of those who had undergone surgical resection (SR) for extrahepatic metastatic lesions. Prognoses made on the basis of extrahepatic metastatic sites were also examined. RESULTS: The survival rates of patients who underwent SR of extrahepatic metastases were significantly better than those of patients who did not receive SR. For the SR group, 1- and 3-year survival rates were 24% and 7%, respectively, while for the non-resection group, the survival rates were 8% and 0%, respectively ( P < 0.0001). Survival rates related to metastatic sites were also significantly superior after SR of extrahepatic metastases: median survivals were 32 mo with lung metastasis, 10 mo with bone metastasis, 6.1 mo with brain metastasis. CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC.

Original languageEnglish
Pages (from-to)5481-5488
Number of pages8
JournalWorld Journal of Gastroenterology
Volume15
Issue number43
DOIs
StatePublished - 21 11 2009

Keywords

  • Extrahepatic metastases
  • Hepatic resection
  • Hepatocellular carcinoma
  • Outcome
  • Surgical resection

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