Electrophilic condensation of pyrimidines with cyclic ketones

On Lee; Hui Po Wang

doi:10.1016/S0040-4039(97)01437-8

Electrophilic condensation of pyrimidines with cyclic ketones

On Lee
, Hui Po Wang^*

^*Corresponding author for this work

National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

Electrophilic condensation of pyrimidines with cyclic ketones was investigated. As nucleophiles, the degree of ionization of pyrimidines in acidic media and the electron density on the C-5 determined the reactivity. An electron-rich nitrogen at the 4-position of cyclic ketones facilitated the reaction. This method is facile for the synthesis of 5-vinyl substituted pyrimidines as k(cat) antifolates.

Original language	English
Pages (from-to)	6401-6404
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	36
DOIs	https://doi.org/10.1016/S0040-4039(97)01437-8
State	Published - 08 09 1997
Externally published	Yes

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10.1016/S0040-4039(97)01437-8

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@article{e5d5ae46cf7b4584b01478c623d44090,

title = "Electrophilic condensation of pyrimidines with cyclic ketones",

abstract = "Electrophilic condensation of pyrimidines with cyclic ketones was investigated. As nucleophiles, the degree of ionization of pyrimidines in acidic media and the electron density on the C-5 determined the reactivity. An electron-rich nitrogen at the 4-position of cyclic ketones facilitated the reaction. This method is facile for the synthesis of 5-vinyl substituted pyrimidines as k(cat) antifolates.",

author = "On Lee and Wang, \{Hui Po\}",

year = "1997",

month = sep,

day = "8",

doi = "10.1016/S0040-4039(97)01437-8",

language = "英语",

volume = "38",

pages = "6401--6404",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "36",

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T1 - Electrophilic condensation of pyrimidines with cyclic ketones

AU - Lee, On

AU - Wang, Hui Po

PY - 1997/9/8

Y1 - 1997/9/8

N2 - Electrophilic condensation of pyrimidines with cyclic ketones was investigated. As nucleophiles, the degree of ionization of pyrimidines in acidic media and the electron density on the C-5 determined the reactivity. An electron-rich nitrogen at the 4-position of cyclic ketones facilitated the reaction. This method is facile for the synthesis of 5-vinyl substituted pyrimidines as k(cat) antifolates.

AB - Electrophilic condensation of pyrimidines with cyclic ketones was investigated. As nucleophiles, the degree of ionization of pyrimidines in acidic media and the electron density on the C-5 determined the reactivity. An electron-rich nitrogen at the 4-position of cyclic ketones facilitated the reaction. This method is facile for the synthesis of 5-vinyl substituted pyrimidines as k(cat) antifolates.

UR - https://www.scopus.com/pages/publications/0030765709

U2 - 10.1016/S0040-4039(97)01437-8

DO - 10.1016/S0040-4039(97)01437-8

M3 - 文章

AN - SCOPUS:0030765709

SN - 0040-4039

VL - 38

SP - 6401

EP - 6404

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Electrophilic condensation of pyrimidines with cyclic ketones

Abstract

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