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Electroretinogram (ERG) to Evaluate the Retina Using Mouse Models

  • Pei Kang Liu
  • , Wan Chun Huang
  • , Nan Kai Wang*
  • *Corresponding author for this work
  • Columbia University
  • Kaohsiung Medical University
  • National Sun Yat-sen University

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

Electroretinogram (ERG) is a sensitive and useful tool for the measurement of the retina’s electrical response to flash stimuli. It provides a functional evaluation of the photoreceptors and downstream associated retinal cells. Similar to those conducted on humans, mouse ERGs include the amplitudes of a- and b-waves as well as the implicit time from those ERGs. Applications of ERGs include identification of retinal phenotypes, measurement of retinal function (at one and various time points), and evaluation of treatment efficacy. However, there are some differences between the manifestation of disease in patients as compared to mouse models that should be taken into consideration when implementing mouse ERGs. Herein, this chapter will introduce how to perform and obtain mouse ERGs.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages217-227
Number of pages11
Volume2560
DOIs
StatePublished - 2023

Publication series

NameMethods in molecular biology (Clifton, N.J.)
ISSN (Print)1064-3745

Bibliographical note

© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Electroretinogram (ERG)
  • Full-field ERG
  • Mouse model
  • Serial intensity ERG
  • Electroretinography
  • Animals
  • Humans
  • Mice

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