TY - JOUR
T1 - Electrospun collagen/chitosan nanofibrous membrane as wound dressing
AU - Chen, Jyh Ping
AU - Chang, Gwo Yun
AU - Chen, Jan Kan
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Composite nanofibrous membranes (NFM) of type I collagen, chitosan, and polyethylene oxide was fabricated by electrospinning, which could be further crosslinked by glutaraldehyde vapor. The NFM was subject to detailed analysis by scanning electron microscopy, scanning probe microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy, and tensile testing. Nanofiber diameter was found to be 134 ± 42 nm, which increased to 398 ± 76 nm after crosslinking. The Young's modulus increased after crosslinking, however, the ultimate tensile strength, tensile strain, and water sorption capability decreased after crosslinking. NFMs showed no cytotoxicity toward growth of 3T3 fibroblasts and had good in vitro biocompatibility. From animal studies, the NFM was better than gauze and commercial collagen sponge wound dressing in wound healing rate. This novel electrospun matrix will have potential as a wound dressing for skin regeneration.
AB - Composite nanofibrous membranes (NFM) of type I collagen, chitosan, and polyethylene oxide was fabricated by electrospinning, which could be further crosslinked by glutaraldehyde vapor. The NFM was subject to detailed analysis by scanning electron microscopy, scanning probe microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy, and tensile testing. Nanofiber diameter was found to be 134 ± 42 nm, which increased to 398 ± 76 nm after crosslinking. The Young's modulus increased after crosslinking, however, the ultimate tensile strength, tensile strain, and water sorption capability decreased after crosslinking. NFMs showed no cytotoxicity toward growth of 3T3 fibroblasts and had good in vitro biocompatibility. From animal studies, the NFM was better than gauze and commercial collagen sponge wound dressing in wound healing rate. This novel electrospun matrix will have potential as a wound dressing for skin regeneration.
KW - Electrospinning
KW - Nanofabrication
KW - Nanofibers
KW - Wound dressing
UR - http://www.scopus.com/inward/record.url?scp=37349131624&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2007.04.129
DO - 10.1016/j.colsurfa.2007.04.129
M3 - 文章
AN - SCOPUS:37349131624
SN - 0927-7757
VL - 313-314
SP - 183
EP - 188
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
ER -