Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients

Chia Hsing Huang, Mao Liang Chen, Yu Lin Tsai, Ming Ta Tsai, Chia Hsiang Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

15 Scopus citations


Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of mental diseases. Using real-time quantitative PCR, we compared the ADM mRNA levels in lymphoblastoid cell lines between schizophrenic patients and controls. Male but not female schizophrenia patients had 2- to 3-fold higher ADM mRNA levels than controls (p < 0.01). Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study.

Original languageEnglish
Pages (from-to)1443-1446
Number of pages4
Issue number9
StatePublished - 28 06 2004
Externally publishedYes


  • Adrenomedullin
  • Association
  • Biomarker
  • Lymphoblastoid cells
  • Pathophysiology
  • Schizophrenia


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