Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients

Chia Hsing Huang; Mao Liang Chen; Yu Lin Tsai; Ming Ta Tsai; Chia Hsiang Chen

doi:10.1097/01.wnr.0000132202.69212.79

Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients

Chia Hsing Huang, Mao Liang Chen, Yu Lin Tsai, Ming Ta Tsai, Chia Hsiang Chen^*

^*Corresponding author for this work

Tzu Chi University

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of mental diseases. Using real-time quantitative PCR, we compared the ADM mRNA levels in lymphoblastoid cell lines between schizophrenic patients and controls. Male but not female schizophrenia patients had 2- to 3-fold higher ADM mRNA levels than controls (p < 0.01). Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study.

Original language	English
Pages (from-to)	1443-1446
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	9
DOIs	https://doi.org/10.1097/01.wnr.0000132202.69212.79
State	Published - 28 06 2004
Externally published	Yes

Keywords

Adrenomedullin
Association
Biomarker
Lymphoblastoid cells
Pathophysiology
Schizophrenia

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10.1097/01.wnr.0000132202.69212.79

Cite this

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abstract = "Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of mental diseases. Using real-time quantitative PCR, we compared the ADM mRNA levels in lymphoblastoid cell lines between schizophrenic patients and controls. Male but not female schizophrenia patients had 2- to 3-fold higher ADM mRNA levels than controls (p < 0.01). Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study.",

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Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients

Abstract

Keywords

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