Elucidating bidirectional relationship between metabolic syndrome and elevated faecal haemoglobin concentration: A Taiwanese community-based cohort study

Mei Sheng Ku, Jean Ching Yuan Fann, Sherry Yueh Hsia Chiu, Hsiu Hsi Chen*, Chen Yang Hsu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

Objectives To elucidate the bidirectional temporal relationship between elevated faecal haemoglobin (f-Hb) concentration and metabolic syndrome (MetS). Design A longitudinal cohort study was conducted by utilising data on community-based periodical screening for colorectal cancer with faecal immunochemical test (FIT) and health check-up for MetS. Setting Population-based organised integrated service screening in Keelung city, Taiwan. Participants We enrolled a total of 62,293 community residents aged 40-79 years. Main outcomes and measures Bidirectional outcomes of FIT-positive and MetS were measured. Results The presence of MetS at baseline led to a statistically significant 31% elevated risk of being incident FIT-positive (adjusted HR, (aHR)=1.31, 95% CI: 1.14 to 1.51) whereas the effect of those with FIT-positive at baseline on incident MetS was not statistically significant (aHR=1.06, 95% CI: 0.89 to 1.25) after adjusting for relevant confounders. Such an effect was particularly noted for three individual components (abnormal waist circumference, higher fasting plasma glucose and lower high-density lipoprotein). Conclusions Our finding on the presence of MetS before FIT-positive based on bidirectional relationship assessment suggests the control of MetS may contribute to reducing the risk of colorectal neoplasia through the early surveillance of f-Hb. However, such a temporal epidemiological finding still needs to be verified by using other external data.

Original languageEnglish
Article numbere021153
JournalBMJ Open
Volume9
Issue number3
DOIs
StatePublished - 01 03 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords

  • colorectal cancer
  • faecal haemoglobin concentration
  • metabolic syndrome

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