Emergence of oxacillin-resistant Staphylococcus lugdunensis carrying staphylococcal cassette chromosome mec type V in central Taiwan

Ting Yu Yen, Yun Ju Sung, Hsiao Chuan Lin, Ching Tien Peng, Ni Tien, Kao Pin Hwang, Jang Jih Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

Background Staphylococcus lugdunensis has emerged as a key pathogen for clinical infection. It is sensitive to most antistaphylococcal agents, but it is increasingly resistant to β-lactam antibiotics. Oxacillin-resistant S. lugdunensis isolates carrying the mecA gene pose a major concern for therapy failure. Methods To assess the epidemiology and presence of mecA in S. lugdunensis, we gauged the prevalence and antibiotic resistance of S. lugdunensis in clinical specimens by using multiplex polymerase chain reaction (PCR) and pulsed-field gel electrophoresis. Results Thirty S. lugdunensis isolates were collected and examined between October 2009 and December 2010. The resistance to penicillin (87%) and oxacillin (20%) was noted. All oxacillin-resistant isolates (6/30) had type V or VT SCCmec. Most (67%, 4/6) isolates carried SCCmec type V. These organisms caused invasive infections such as peritonitis, osteomyelitis, and septic arthritis. Pulsed-field gel electrophoresis analyses showed most (83%, 5/6) isolates carrying mecA were pulsotype D with high similarity (93.8%). Conclusions The findings suggest oxacillin-resistant S. lugdunensis carrying SCCmec type V is emerging in central Taiwan.

Original languageEnglish
Pages (from-to)885-891
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Volume49
Issue number6
DOIs
StatePublished - 01 12 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014

Keywords

  • SCCmec gene
  • Staphylococcus lugdunensis
  • coagulase-negative staphylococcus
  • oxacillin resistance

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