Emerging picture of host chaperone and cyclophilin roles in RNA virus replication

P. D. Nagy; R. Y. Wang; J. Pogany; A. Hafren; K. Makinen

doi:10.1016/j.virol.2010.12.061

Emerging picture of host chaperone and cyclophilin roles in RNA virus replication

P. D. Nagy^*
, R. Y. Wang
, J. Pogany
, A. Hafren
, K. Makinen

^*Corresponding author for this work

Master & PhD Program in Biotechnology Industry

University of Kentucky
University of Helsinki

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

Original language	English
Pages (from-to)	374-382
Number of pages	9
Journal	Virology
Volume	411
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2010.12.061
State	Published - 15 03 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cyclophilins
Flock house virus
Heat shock proteins
Hepatitis C virus
Host factors
Hsp70
Immunophilins
RNA viruses
Tomato bushy stunt virus
Virus replication

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10.1016/j.virol.2010.12.061

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title = "Emerging picture of host chaperone and cyclophilin roles in RNA virus replication",

abstract = "Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.",

keywords = "Cyclophilins, Flock house virus, Heat shock proteins, Hepatitis C virus, Host factors, Hsp70, Immunophilins, RNA viruses, Tomato bushy stunt virus, Virus replication",

author = "Nagy, \{P. D.\} and Wang, \{R. Y.\} and J. Pogany and A. Hafren and K. Makinen",

year = "2011",

month = mar,

day = "15",

doi = "10.1016/j.virol.2010.12.061",

language = "英语",

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journal = "Virology",

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TY - JOUR

T1 - Emerging picture of host chaperone and cyclophilin roles in RNA virus replication

AU - Nagy, P. D.

AU - Wang, R. Y.

AU - Pogany, J.

AU - Hafren, A.

AU - Makinen, K.

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

AB - Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

KW - Cyclophilins

KW - Flock house virus

KW - Heat shock proteins

KW - Hepatitis C virus

KW - Host factors

KW - Hsp70

KW - Immunophilins

KW - RNA viruses

KW - Tomato bushy stunt virus

KW - Virus replication

UR - https://www.scopus.com/pages/publications/79952071414

U2 - 10.1016/j.virol.2010.12.061

DO - 10.1016/j.virol.2010.12.061

M3 - 文献综述

C2 - 21295323

AN - SCOPUS:79952071414

SN - 0042-6822

VL - 411

SP - 374

EP - 382

JO - Virology

JF - Virology

IS - 2

ER -

Emerging picture of host chaperone and cyclophilin roles in RNA virus replication

Abstract

UN SDGs

Keywords

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