Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms

Tariq I. Mughal*, Naveen Pemmaraju, Jerald P. Radich, Michael W. Deininger, Nicole Kucine, Jean Jacques Kiladjian, Prithviraj Bose, Jason Gotlib, Peter Valent, Chih Cheng Chen, Tiziano Barbui, Raajit Rampal, Srdan Verstovsek, Steffen Koschmieder, Giuseppe Saglio, Richard A. Van Etten

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The 60th American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13th Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on December 4 and 5, 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues that require clarity. We discuss the experimental and observational evidence to support the intimate interaction between aging, inflammation, and clonal evolution of MPNs, the clinical impact of the unfolding mutational landscape on the emerging targets and treatment of MPNs, new methods to detect clonal heterogeneity, the challenges in managing childhood and adolescent MPN, and reflect on the treatment of systemic mastocytosis (SM) following the licensing of midostaurin.

Original languageEnglish
Pages (from-to)240-252
Number of pages13
JournalHematological Oncology
Issue number3
StatePublished - 08 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.


  • IFNα
  • MPNs
  • clonal heterogeneity
  • inflammaging
  • investigational therapies


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