Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field

Tefera Worku Mekonnen; Yihenew Simegniew Birhan; Abegaz Tizazu Andrgie; Endiries Yibru Hanurry; Haile Fentahun Darge; Hsiao Ying Chou; Juin Yih Lai; Hsieh Chih Tsai; Jen Ming Yang; Yen Hsiang Chang

doi:10.1016/j.colsurfb.2019.110531

Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field

Tefera Worku Mekonnen, Yihenew Simegniew Birhan, Abegaz Tizazu Andrgie, Endiries Yibru Hanurry, Haile Fentahun Darge, Hsiao Ying Chou, Juin Yih Lai, Hsieh Chih Tsai^*, Jen Ming Yang, Yen Hsiang Chang

^*Corresponding author for this work

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Journal Article › peer-review

39 Scopus citations

Abstract

Iron oxide-based magnetic resonance imaging (MRI) contrast agents have negative contrast limitations in cancer diagnosis. Gadolinium (Gd)-based contrast agents show toxicity. To overcome these limitations, Gd-doped ferrite (Gd:Fe₃O₄ (GdIO) nanoparticles (NPs) were synthesized as T1-T2 dual-modal contrast agents for MRI-traced drug delivery. A theranostics GdIO encapsulated in a Generation 4.5 PAMAM dendrimer (G4.5-GdIO) was developed by alkaline coprecipitation. The drug-loading efficiency of the NPs was ∼24%. In the presence of a low-frequency alternating magnetic field (LFAMF), a maximum cumulative doxorubicin (DOX) release of ∼77.47% was achieved in a mildly acidic (pH = 5.0) simulated endosomal microenvironment. Relaxometric measurements indicated superior r1 (5.19 mM⁻¹s⁻¹) and r2 (26.13 mM⁻¹s⁻¹) for G4.5-GdIO relative to commercially available Gd-DTPA. Thus, G4.5-GdIO is promising as an alternative noninvasive MRI-traced cancer drug delivery system.

Original language	English
Article number	110531
Journal	Colloids and Surfaces B: Biointerfaces
Volume	184
DOIs	https://doi.org/10.1016/j.colsurfb.2019.110531
State	Published - 01 12 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Cancer
Encapsulation
Gadolinium ferrite
Magnetic field
Poly(amidoamine)
Theranostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.colsurfb.2019.110531

Cite this

Mekonnen, T. W., Birhan, Y. S., Andrgie, A. T., Hanurry, E. Y., Darge, H. F., Chou, H. Y., Lai, J. Y., Tsai, H. C., Yang, J. M., & Chang, Y. H. (2019). Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field. Colloids and Surfaces B: Biointerfaces, 184, Article 110531. https://doi.org/10.1016/j.colsurfb.2019.110531

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title = "Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field",

abstract = "Iron oxide-based magnetic resonance imaging (MRI) contrast agents have negative contrast limitations in cancer diagnosis. Gadolinium (Gd)-based contrast agents show toxicity. To overcome these limitations, Gd-doped ferrite (Gd:Fe3O4 (GdIO) nanoparticles (NPs) were synthesized as T1-T2 dual-modal contrast agents for MRI-traced drug delivery. A theranostics GdIO encapsulated in a Generation 4.5 PAMAM dendrimer (G4.5-GdIO) was developed by alkaline coprecipitation. The drug-loading efficiency of the NPs was ∼24%. In the presence of a low-frequency alternating magnetic field (LFAMF), a maximum cumulative doxorubicin (DOX) release of ∼77.47% was achieved in a mildly acidic (pH = 5.0) simulated endosomal microenvironment. Relaxometric measurements indicated superior r1 (5.19 mM−1s−1) and r2 (26.13 mM−1s−1) for G4.5-GdIO relative to commercially available Gd-DTPA. Thus, G4.5-GdIO is promising as an alternative noninvasive MRI-traced cancer drug delivery system.",

keywords = "Cancer, Encapsulation, Gadolinium ferrite, Magnetic field, Poly(amidoamine), Theranostics",

author = "Mekonnen, {Tefera Worku} and Birhan, {Yihenew Simegniew} and Andrgie, {Abegaz Tizazu} and Hanurry, {Endiries Yibru} and Darge, {Haile Fentahun} and Chou, {Hsiao Ying} and Lai, {Juin Yih} and Tsai, {Hsieh Chih} and Yang, {Jen Ming} and Chang, {Yen Hsiang}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.colsurfb.2019.110531",

language = "英语",

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Mekonnen, TW, Birhan, YS, Andrgie, AT, Hanurry, EY, Darge, HF, Chou, HY, Lai, JY, Tsai, HC, Yang, JM & Chang, YH 2019, 'Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field', Colloids and Surfaces B: Biointerfaces, vol. 184, 110531. https://doi.org/10.1016/j.colsurfb.2019.110531

Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field. / Mekonnen, Tefera Worku; Birhan, Yihenew Simegniew; Andrgie, Abegaz Tizazu et al.
In: Colloids and Surfaces B: Biointerfaces, Vol. 184, 110531, 01.12.2019.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field

AU - Mekonnen, Tefera Worku

AU - Birhan, Yihenew Simegniew

AU - Andrgie, Abegaz Tizazu

AU - Hanurry, Endiries Yibru

AU - Darge, Haile Fentahun

AU - Chou, Hsiao Ying

AU - Lai, Juin Yih

AU - Tsai, Hsieh Chih

AU - Yang, Jen Ming

AU - Chang, Yen Hsiang

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Iron oxide-based magnetic resonance imaging (MRI) contrast agents have negative contrast limitations in cancer diagnosis. Gadolinium (Gd)-based contrast agents show toxicity. To overcome these limitations, Gd-doped ferrite (Gd:Fe3O4 (GdIO) nanoparticles (NPs) were synthesized as T1-T2 dual-modal contrast agents for MRI-traced drug delivery. A theranostics GdIO encapsulated in a Generation 4.5 PAMAM dendrimer (G4.5-GdIO) was developed by alkaline coprecipitation. The drug-loading efficiency of the NPs was ∼24%. In the presence of a low-frequency alternating magnetic field (LFAMF), a maximum cumulative doxorubicin (DOX) release of ∼77.47% was achieved in a mildly acidic (pH = 5.0) simulated endosomal microenvironment. Relaxometric measurements indicated superior r1 (5.19 mM−1s−1) and r2 (26.13 mM−1s−1) for G4.5-GdIO relative to commercially available Gd-DTPA. Thus, G4.5-GdIO is promising as an alternative noninvasive MRI-traced cancer drug delivery system.

AB - Iron oxide-based magnetic resonance imaging (MRI) contrast agents have negative contrast limitations in cancer diagnosis. Gadolinium (Gd)-based contrast agents show toxicity. To overcome these limitations, Gd-doped ferrite (Gd:Fe3O4 (GdIO) nanoparticles (NPs) were synthesized as T1-T2 dual-modal contrast agents for MRI-traced drug delivery. A theranostics GdIO encapsulated in a Generation 4.5 PAMAM dendrimer (G4.5-GdIO) was developed by alkaline coprecipitation. The drug-loading efficiency of the NPs was ∼24%. In the presence of a low-frequency alternating magnetic field (LFAMF), a maximum cumulative doxorubicin (DOX) release of ∼77.47% was achieved in a mildly acidic (pH = 5.0) simulated endosomal microenvironment. Relaxometric measurements indicated superior r1 (5.19 mM−1s−1) and r2 (26.13 mM−1s−1) for G4.5-GdIO relative to commercially available Gd-DTPA. Thus, G4.5-GdIO is promising as an alternative noninvasive MRI-traced cancer drug delivery system.

KW - Cancer

KW - Encapsulation

KW - Gadolinium ferrite

KW - Magnetic field

KW - Poly(amidoamine)

KW - Theranostics

UR - http://www.scopus.com/inward/record.url?scp=85072808403&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfb.2019.110531

DO - 10.1016/j.colsurfb.2019.110531

M3 - 文章

C2 - 31590053

AN - SCOPUS:85072808403

SN - 0927-7765

VL - 184

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

M1 - 110531

ER -

Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field

Abstract

Bibliographical note

Keywords

UN SDGs

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