Abstract
Objective Experiments were designed to investigate the effect of Euro-Collins (EC) solution and University of Wisconsin (UW) solution on function of pulmonary arterial endothelium. Methods Third order canine pulmonary artery segments were preserved in cold (4°C) UW (group 1, n = 8) or EC (group 2, n = 9) solutions for 16 hours. The preserved (group 1 and 2) and control (group 3, n = 7) pulmonary arterial segments with and without endothelium were studied in vitro in organ chambers to measure isometric tension. Results The endothelium-dependent relaxation to acetylcholine and adenosine diphosphate of group 1 and 3 were significantly better than those of group 2. Conclusions We concluded that endotheliumdependent relaxation of canine pulmonary arterial endothelium to receptor-dependent acetylcholine and adenosine diphosphate were impaired after preservation with Euro-Collins solution. However, endothelium-dependent relaxation of pulmonary segments were well maintained after preservation with University of Wisconsin solution.
| Original language | English |
|---|---|
| Pages (from-to) | 330-333 |
| Number of pages | 4 |
| Journal | Chinese Medical Journal |
| Volume | 111 |
| Issue number | 4 |
| State | Published - 1998 |
| Externally published | Yes |