Enhanced accumulation of 5-Fluorouracil in human tumors in athymic mice by co-administration of Ftorafur and Uracil

Simon G. Tang*, Cecil L. Hornbeck, John E. Byfield

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

Human colonic tumors grown in athymic mice were tested for the effect of coincident uracil (U) and Ftorafur (FT) exposure versus FT alone on 5-Fluorouracil (5-FU) metabolism. Serum and tumor FT and 5-FU levels were studied as a function of time after FT +/- U injections. The combination of U + FT led to significantly higher tumor/serum 5-FU ratios than FT alone. The data indicate that the metabolism of 5-FU released from FT can be modulated by coincident U exposure in human tumor cells in vivo. Such combinations may be of use in the development of oral 5-FU pro-drugs for applications using 5-FU as an out-patient non-invasive radiosensitizer.

Original languageEnglish
Pages (from-to)1687-1689
Number of pages3
JournalInternational Journal of Radiation Oncology Biology Physics
Volume10
Issue number9
DOIs
StatePublished - 09 1984
Externally publishedYes

Keywords

  • 5-Fluorouracil
  • Athymic mice
  • Ftorafur
  • Pharmacokinetics
  • Radiosensitization

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