Enhanced mechanical and biological performances of CaO-MgO-SiO2 glass-ceramics via the modulation of glass and ceramic phases

Kuei Chih Feng; Yu Jie Wu; Chi Yun Wang; Chi Shun Tu; Yu Ling Lin; Cheng Sao Chen; Po Liang Lai; Yu Tzu Huang; Pin Yi Chen

doi:10.1016/j.msec.2021.112060

Enhanced mechanical and biological performances of CaO-MgO-SiO₂ glass-ceramics via the modulation of glass and ceramic phases

Kuei Chih Feng, Yu Jie Wu, Chi Yun Wang, Chi Shun Tu, Yu Ling Lin, Cheng Sao Chen, Po Liang Lai, Yu Tzu Huang^*, Pin Yi Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

This work reports a new CaO-MgO-SiO₂ (CMS) bioactive glass-ceramic, using ZrO₂ as a nucleus to modulate the ratios of glass and ceramic phases as a function of sintering temperature. Mg-rich bioactive CMS glass-ceramics exhibit advantages regarding mechanical strength (flexural strength ~190 MPa and compressive strength ~555 MPa), in-vitro and in-vivo biocompatibilities, and bone ingrowth. The high mechanical strengths could be attributed to the CaMgSi₂O₆ glass-ceramic and lower porosity. X-ray absorption spectra indicate an increased Si–O covalent bond via the development of CaMgSi₂O₆ glass-ceramics. From the in-vitro cytotoxicity and BMSC differentiation assays, the CMS samples sintered above 800 °C exhibited better cell attachment and differentiation, possibly due to structural stability, appropriate pore, and ion release to boost osteogenesis. Compared to hydroxyapatite (HA) ceramics, the CMS glass-ceramics display higher mechanical strengths, biocompatibility, and osteoconductivity. An in-vivo experiment demonstrated a fine bone-ingrowth profile around the CMS implant. This study may further the application of CMS glass-ceramics in bone implants.

Original language	English
Article number	112060
Journal	Materials Science and Engineering C
Volume	124
DOIs	https://doi.org/10.1016/j.msec.2021.112060
State	Published - 05 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Biocompatibility
CaO-MgO-SiO glass-ceramics
Mechanical strength

Access to Document

10.1016/j.msec.2021.112060

Cite this

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title = "Enhanced mechanical and biological performances of CaO-MgO-SiO2 glass-ceramics via the modulation of glass and ceramic phases",

abstract = "This work reports a new CaO-MgO-SiO2 (CMS) bioactive glass-ceramic, using ZrO2 as a nucleus to modulate the ratios of glass and ceramic phases as a function of sintering temperature. Mg-rich bioactive CMS glass-ceramics exhibit advantages regarding mechanical strength (flexural strength ~190 MPa and compressive strength ~555 MPa), in-vitro and in-vivo biocompatibilities, and bone ingrowth. The high mechanical strengths could be attributed to the CaMgSi2O6 glass-ceramic and lower porosity. X-ray absorption spectra indicate an increased Si–O covalent bond via the development of CaMgSi2O6 glass-ceramics. From the in-vitro cytotoxicity and BMSC differentiation assays, the CMS samples sintered above 800 °C exhibited better cell attachment and differentiation, possibly due to structural stability, appropriate pore, and ion release to boost osteogenesis. Compared to hydroxyapatite (HA) ceramics, the CMS glass-ceramics display higher mechanical strengths, biocompatibility, and osteoconductivity. An in-vivo experiment demonstrated a fine bone-ingrowth profile around the CMS implant. This study may further the application of CMS glass-ceramics in bone implants.",

keywords = "Biocompatibility, CaO-MgO-SiO glass-ceramics, Mechanical strength",

author = "Feng, {Kuei Chih} and Wu, {Yu Jie} and Wang, {Chi Yun} and Tu, {Chi Shun} and Lin, {Yu Ling} and Chen, {Cheng Sao} and Lai, {Po Liang} and Huang, {Yu Tzu} and Chen, {Pin Yi}",

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year = "2021",

month = may,

doi = "10.1016/j.msec.2021.112060",

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volume = "124",

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AU - Feng, Kuei Chih

AU - Wu, Yu Jie

AU - Wang, Chi Yun

AU - Tu, Chi Shun

AU - Lin, Yu Ling

AU - Chen, Cheng Sao

AU - Lai, Po Liang

AU - Huang, Yu Tzu

AU - Chen, Pin Yi

PY - 2021/5

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AB - This work reports a new CaO-MgO-SiO2 (CMS) bioactive glass-ceramic, using ZrO2 as a nucleus to modulate the ratios of glass and ceramic phases as a function of sintering temperature. Mg-rich bioactive CMS glass-ceramics exhibit advantages regarding mechanical strength (flexural strength ~190 MPa and compressive strength ~555 MPa), in-vitro and in-vivo biocompatibilities, and bone ingrowth. The high mechanical strengths could be attributed to the CaMgSi2O6 glass-ceramic and lower porosity. X-ray absorption spectra indicate an increased Si–O covalent bond via the development of CaMgSi2O6 glass-ceramics. From the in-vitro cytotoxicity and BMSC differentiation assays, the CMS samples sintered above 800 °C exhibited better cell attachment and differentiation, possibly due to structural stability, appropriate pore, and ion release to boost osteogenesis. Compared to hydroxyapatite (HA) ceramics, the CMS glass-ceramics display higher mechanical strengths, biocompatibility, and osteoconductivity. An in-vivo experiment demonstrated a fine bone-ingrowth profile around the CMS implant. This study may further the application of CMS glass-ceramics in bone implants.

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