Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin

Li Wen Zhang; Yi Ping Fang; Jia You Fang

doi:10.1016/j.dsi.2011.02.002

Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin

Li Wen Zhang, Yi Ping Fang, Jia You Fang^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as iontophoresis, laser, microneedles, ultrasound, and by adding chemical penetration enhancers, such as, dimethyl sulfoxide, oleic acid, and others, whereas some researches used lipophilic ALA derivatives and different vehicles to improve the transdermal delivery of ALA. This review introduces several enhancement techniques for increasing ALA permeation through the skin.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Dermatologica Sinica
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.dsi.2011.02.002
State	Published - 03 2011

Keywords

5-Aminolevulinic acid (ALA)
Enhancers
Penetration
Photodynamic therapy
Transdermal drug delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dsi.2011.02.002

Cite this

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title = "Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin",

abstract = "Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as iontophoresis, laser, microneedles, ultrasound, and by adding chemical penetration enhancers, such as, dimethyl sulfoxide, oleic acid, and others, whereas some researches used lipophilic ALA derivatives and different vehicles to improve the transdermal delivery of ALA. This review introduces several enhancement techniques for increasing ALA permeation through the skin.",

keywords = "5-Aminolevulinic acid (ALA), Enhancers, Penetration, Photodynamic therapy, Transdermal drug delivery",

author = "Zhang, {Li Wen} and Fang, {Yi Ping} and Fang, {Jia You}",

year = "2011",

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T1 - Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin

AU - Zhang, Li Wen

AU - Fang, Yi Ping

AU - Fang, Jia You

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N2 - Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as iontophoresis, laser, microneedles, ultrasound, and by adding chemical penetration enhancers, such as, dimethyl sulfoxide, oleic acid, and others, whereas some researches used lipophilic ALA derivatives and different vehicles to improve the transdermal delivery of ALA. This review introduces several enhancement techniques for increasing ALA permeation through the skin.

AB - Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as iontophoresis, laser, microneedles, ultrasound, and by adding chemical penetration enhancers, such as, dimethyl sulfoxide, oleic acid, and others, whereas some researches used lipophilic ALA derivatives and different vehicles to improve the transdermal delivery of ALA. This review introduces several enhancement techniques for increasing ALA permeation through the skin.

KW - 5-Aminolevulinic acid (ALA)

KW - Enhancers

KW - Penetration

KW - Photodynamic therapy

KW - Transdermal drug delivery

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M3 - 文献综述

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JO - Dermatologica Sinica

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Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin

Abstract

Keywords

UN SDGs

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