Environmental stimulation rescues maternal high fructose intake-impaired learning and memory in female offspring: Its correlation with redistribution of histone deacetylase 4

Kay L.H. Wu*, Chih Wei Wu, You Lin Tain, Li Tung Huang, Yung Mei Chao, Chun Ying Hung, Jin Cheng Wu, Siang Ru Chen, Pei Chia Tsai, Julie Y.H. Chan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

29 Scopus citations

Abstract

Impairment of learning and memory has been documented in the later life of offspring to maternal consumption with high energy diet. Environmental stimulation enhances the ability of learning and memory. However, potential effects of environmental stimulation on the programming-associated deficit of learning and memory have not been addressed. Here, we examined the effects of enriched-housing on hippocampal learning and memory in adult female offspring rats from mother fed with 60% high fructose diet (HFD) during pregnancy and lactation. Impairment of spatial learning and memory performance in HFD group was observed in offspring at 3-month-old. Hippocampal brain-derived neurotrophic factor (BDNF) was decreased in the offspring. Moreover, the HFD group showed an up-regulation of histone deacetylase 4 (HDAC4) in the nuclear fractions of hippocampal neurons. Stimulation to the offspring for 4 weeks after winning with an enriched-housing environment effectively rescued the decrease in cognitive function and hippocampal BDNF level; alongside a reversal of the increased distribution of nuclear HDAC4. Together these results suggest that later life environmental stimulation effectively rescues the impairment of hippocampal learning and memory in female offspring to maternal HFD intake through redistributing nuclear HDAC4 to increase BDNF expression.

Original languageEnglish
Pages (from-to)105-117
Number of pages13
JournalNeurobiology of Learning and Memory
Volume130
DOIs
StatePublished - 01 04 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

  • BDNF
  • Environmental stimulation
  • HDAC4
  • Maternal high fructose diet
  • Offspring learning and memory

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