Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid

Hong Hu Chen; Ai Hua Sun; David M. Ojcius; Wei Lin Hu; Yu Mei Ge; Xu'ai Lin; Lan Juan Li; Jian Ping Pan; Jie Yan

doi:10.1371/journal.pone.0142881

Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid

Hong Hu Chen
, Ai Hua Sun
, David M. Ojcius
, Wei Lin Hu
, Yu Mei Ge
, Xu'ai Lin
, Lan Juan Li
, Jian Ping Pan
, Jie Yan

Research output: Contribution to journal › Journal Article › peer-review

28 Scopus citations

Abstract

Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naive T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-β1 and ATRA.

Original language	English
Article number	e0142881
Journal	PLoS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0142881
State	Published - 01 11 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Chen et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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10.1371/journal.pone.0142881

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title = "Eosinophils from murine lamina propria induce differentiation of na{\"i}ve T cells into regulatory T cells via TGF-β1 and retinoic acid",

abstract = "Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naive T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-β1 and ATRA.",

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T1 - Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid

AU - Chen, Hong Hu

AU - Sun, Ai Hua

AU - Ojcius, David M.

AU - Hu, Wei Lin

AU - Ge, Yu Mei

AU - Lin, Xu'ai

AU - Li, Lan Juan

AU - Pan, Jian Ping

AU - Yan, Jie

N1 - Publisher Copyright: © 2015 Chen et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naive T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-β1 and ATRA.

AB - Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naive T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-β1 and ATRA.

UR - https://www.scopus.com/pages/publications/84957991575

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ER -

Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid

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