Epidemiology of fatal/non-fatal suicide among patients with chronic osteomyelitis (COM): a nationwide population-based study

Chih Hung Hung, Jih Yang Ko, Pei Shao Liao, Chen Wei Yeh, Chieh Cheng Hsu, Mei Chen Lin, Horng Chaung Hsu, Shu Jui Kuo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


Objective: Chronic osteomyelitis (COM) can induce systemic inflammation, and systemic inflammation may be associated with suicide tendency. However, no studies have investigated the correlation between COM and suicide tendency. Methods: The aim of this population-based study was to determine the epidemiology of fatal/non-fatal suicide among COM patients. Subjects with at least two outpatient visits or one course of inpatient care diagnosed with COM were recruited into a COM cohort. The control/COM subject ratio was approximately 4:1 matched by age, sex, major depression coding and index year (COM patients). Subjects with suicide attempts before COM diagnosis and subjects aged <20 years were excluded. Results: COM patients had 1.93 (95% confidence interval [CI]: 1.11–3.36) times the risk of fatal/non-fatal suicide as control subjects. Considering death as the competing event of fatal/non-fatal suicide, COM patients had 1.76 (95% CI: 1.03–3.01) times the risk of fatal/non-fatal suicide (competing risk regression model). The effect of COM on fatal/non-fatal suicide was more prominent among diabetic patients. COM severity also correlated with the risk of fatal/non-fatal suicide. Conclusions: More attention must be paid to suicide tendency among COM patients.

Original languageEnglish
JournalJournal of International Medical Research
Issue number6
StatePublished - 06 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.


  • Chronic osteomyelitis
  • depression
  • diabetes
  • schizophrenia
  • suicide
  • systemic inflammation


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