Epidermal growth factor receptor mutations in patients with oral cavity cancer in a betel nut chewing-prevalent area

Chia Hsun Hsieh, John W.C. Chang, Jia Juan Hsieh, Todd Hsu, Shiu Feng Huang, Chun Ta Liao, Hung Ming Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

20 Scopus citations

Abstract

Background Epidermal growth factor receptor (EGFR) mutations exist in patients with oral cavity squamous cell carcinoma (OSCC), but few data about mutation patterns with clinical outcomes were reported. Methods Fifty-six formalin-fixed paraffin-embedded tumor samples were obtained surgically from OSCC patients. Direct sequencing of EGFR was carried out using nested polymerase chain reaction. The relationship between EGFR status and clinical courses was analyzed. Results Two (3.56%) missense mutations (G857R; L862Q) in exon 20 were identified. Two types of silent mutation, A859A in exon 21 (1.79%) and Q787Q mutations in exon 20 (30.36%), were also found. No mutation was detected in exons 18 and 19. No significant difference in disease-free survival and locoregional control rate was shown between patients with and without Q787Q mutation. Conclusions We identified a high frequency of Q787Q mutation and a less prevalent active EGFR mutation in OSCC patients in Taiwan where betel nut is commonly chewed.

Original languageEnglish
Pages (from-to)1758-1764
Number of pages7
JournalHead and Neck
Volume33
Issue number12
DOIs
StatePublished - 12 2011

Keywords

  • Q787Q mutation
  • epidermal growth factor receptor (EGFR)
  • head and neck neoplasm
  • oral cavity
  • squamous cell carcinoma

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