Abstract
Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and its downstream transcriptional factors, is one of the most important mechanisms inducing epithelial-mesenchymal transition (EMT), which has been widely accepted as a crucial step to generate early stage of tumor metastasis. Accumulating evidence suggests that epigenetic mechanisms play important roles in hypoxia-induced EMT and metastasis. These epigenetic regulations are mediated by various players including chromatin modifiers, transcriptional co-regulators, microRNAs, etc. In this review, we discuss how his tone-modifying enzymes and transcriptional co-regulators regulate EMT under hypoxic conditions. Developed or potential anticancer agents targeting epigenetic molecules regulating hypoxia-induced EMT are also discussed.
Original language | English |
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Pages (from-to) | 1272-1278 |
Number of pages | 7 |
Journal | Current Pharmaceutical Design |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - 01 01 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Bentham Science Publishers.
Keywords
- Chromatin modifier
- Co-regulator
- Epigenetic regulation
- Epithelial-mesenchymal transition
- HIF-1α
- Hypoxia
- Target