Epigenetic regulation of epithelial-mesenchymal transition by hypoxia in cancer: Targets and therapy

Jian Qiu Wang, Kou Juey Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and its downstream transcriptional factors, is one of the most important mechanisms inducing epithelial-mesenchymal transition (EMT), which has been widely accepted as a crucial step to generate early stage of tumor metastasis. Accumulating evidence suggests that epigenetic mechanisms play important roles in hypoxia-induced EMT and metastasis. These epigenetic regulations are mediated by various players including chromatin modifiers, transcriptional co-regulators, microRNAs, etc. In this review, we discuss how his tone-modifying enzymes and transcriptional co-regulators regulate EMT under hypoxic conditions. Developed or potential anticancer agents targeting epigenetic molecules regulating hypoxia-induced EMT are also discussed.

Original languageEnglish
Pages (from-to)1272-1278
Number of pages7
JournalCurrent Pharmaceutical Design
Volume21
Issue number10
DOIs
StatePublished - 01 01 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.

Keywords

  • Chromatin modifier
  • Co-regulator
  • Epigenetic regulation
  • Epithelial-mesenchymal transition
  • HIF-1α
  • Hypoxia
  • Target

Fingerprint

Dive into the research topics of 'Epigenetic regulation of epithelial-mesenchymal transition by hypoxia in cancer: Targets and therapy'. Together they form a unique fingerprint.

Cite this