Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications

Ya Ping Tsai, Kou Juey Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Mammalian cells constantly encounter hypoxia, which is a stress condition occurring during development and physiological processes. To adapt to this inevitable condition, cells develop various mechanisms to cope with this stress and survive. In addition to the activation/stabilization of transcriptional regulators (hypoxia-inducible factors), other epigenetic mechanisms of gene regulation are used. These mechanisms are mediated by various players including transcriptional coregulators, chromatin-modifying complexes, histone modification enzymes and changes in DNA methylation status. Recent progress in all the fields mentioned above has greatly improved the knowledge of how gene regulation contributes to the hypoxic response. This review should shed light on the molecular epigenetic mechanisms of hypoxia-induced gene regulation and help understand the processes adapted by cells to cope with hypoxia.

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalInternational Journal of Cancer
Issue number2
StatePublished - 15 01 2014
Externally publishedYes


  • chromatin modifier
  • epigenetic regulation
  • epithelial-mesenchymal transition
  • hypoxia
  • transcriptional coregulator


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