Epigenetics in Kawasaki Disease

Kuang Den Chen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Purpose of this chapter: The purpose of this review is to discuss recent evidence of epigenetic alterations and their contribution related to the complicated pathogenesis of Kawasaki disease. There have been new observations of epigenetic alterations and their potential role in disease pathogenesis of Kawasaki disease. In recent years, there has been increasing evidence of epigenetic alterations and their potential role in disease pathogenesis of Kawasaki disease. Recent work has focused on clinical application of DNA methylation and miRNA biomarkers in progression of Kawasaki disease and how these epigenetic alterations play a key role in various aspects of the related gene expression. Changes in both DNA methylation and microRNA expression are fertile ground for investigation relating to clinical diagnosis and therapeutic targets in Kawasaki disease. However, current knowledge has relied on small cohorts that more large-scale studies are needed in the future for validation and to understand their target specificity and the efficacy in therapeutic applications of Kawasaki disease.

Original languageEnglish
Title of host publicationKawasaki Disease
PublisherSpringer Nature
Pages117-121
Number of pages5
ISBN (Electronic)9789811929441
ISBN (Print)9789811929434
DOIs
StatePublished - 01 01 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.

Keywords

  • Endothelial microparticles
  • Global DNA hypomethylation
  • Intravenous immunoglobulin
  • Kawasaki disease
  • Pattern recognition receptors
  • microRNAs

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