Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Huihui Fan; Huda I. Atiya; Yeh Wang; Thomas R. Pisanic; Tza Huei Wang; Ie Ming Shih; Kelly K. Foy; Leonard Frisbie; Ronald J. Buckanovich; Alison A. Chomiak; Rochelle L. Tiedemann; Scott B. Rothbart; Chelsea Chandler; Hui Shen; Lan G. Coffman

doi:10.1016/j.celrep.2020.108473

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Huihui Fan
, Huda I. Atiya
, Yeh Wang
, Thomas R. Pisanic
, Tza Huei Wang
, Ie Ming Shih
, Kelly K. Foy
, Leonard Frisbie
, Ronald J. Buckanovich
, Alison A. Chomiak
, Rochelle L. Tiedemann
, Scott B. Rothbart
, Chelsea Chandler
, Hui Shen^*
, Lan G. Coffman^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

47 Scopus citations

Abstract

Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

Original language	English
Article number	108473
Journal	Cell Reports
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.108473
State	Published - 08 12 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

EZH2
WT1
carcinoma-associated mesenchymal stem cells
epigenomic reprogramming
mesenchymal-to-epithelial transition
metastasis
ovarian cancer
tumor microenvironment

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10.1016/j.celrep.2020.108473

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Fan, H., Atiya, H. I., Wang, Y., Pisanic, T. R., Wang, T. H., Shih, I. M., Foy, K. K., Frisbie, L., Buckanovich, R. J., Chomiak, A. A., Tiedemann, R. L., Rothbart, S. B., Chandler, C., Shen, H., & Coffman, L. G. (2020). Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis. Cell Reports, 33(10), Article 108473. https://doi.org/10.1016/j.celrep.2020.108473

@article{fe5bc074162a415baac6f317aac5aecf,

title = "Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis",

abstract = "Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.",

keywords = "EZH2, WT1, carcinoma-associated mesenchymal stem cells, epigenomic reprogramming, mesenchymal-to-epithelial transition, metastasis, ovarian cancer, tumor microenvironment",

author = "Huihui Fan and Atiya, \{Huda I.\} and Yeh Wang and Pisanic, \{Thomas R.\} and Wang, \{Tza Huei\} and Shih, \{Ie Ming\} and Foy, \{Kelly K.\} and Leonard Frisbie and Buckanovich, \{Ronald J.\} and Chomiak, \{Alison A.\} and Tiedemann, \{Rochelle L.\} and Rothbart, \{Scott B.\} and Chelsea Chandler and Hui Shen and Coffman, \{Lan G.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = dec,

day = "8",

doi = "10.1016/j.celrep.2020.108473",

language = "英语",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier B.V.",

number = "10",

}

Fan, H, Atiya, HI, Wang, Y, Pisanic, TR, Wang, TH, Shih, IM, Foy, KK, Frisbie, L, Buckanovich, RJ, Chomiak, AA, Tiedemann, RL, Rothbart, SB, Chandler, C, Shen, H & Coffman, LG 2020, 'Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis', Cell Reports, vol. 33, no. 10, 108473. https://doi.org/10.1016/j.celrep.2020.108473

TY - JOUR

T1 - Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

AU - Fan, Huihui

AU - Atiya, Huda I.

AU - Wang, Yeh

AU - Pisanic, Thomas R.

AU - Wang, Tza Huei

AU - Shih, Ie Ming

AU - Foy, Kelly K.

AU - Frisbie, Leonard

AU - Buckanovich, Ronald J.

AU - Chomiak, Alison A.

AU - Tiedemann, Rochelle L.

AU - Rothbart, Scott B.

AU - Chandler, Chelsea

AU - Shen, Hui

AU - Coffman, Lan G.

PY - 2020/12/8

Y1 - 2020/12/8

N2 - Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

AB - Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

KW - EZH2

KW - WT1

KW - carcinoma-associated mesenchymal stem cells

KW - epigenomic reprogramming

KW - mesenchymal-to-epithelial transition

KW - metastasis

KW - ovarian cancer

KW - tumor microenvironment

UR - https://www.scopus.com/pages/publications/85097460523

U2 - 10.1016/j.celrep.2020.108473

DO - 10.1016/j.celrep.2020.108473

M3 - 文章

C2 - 33296650

AN - SCOPUS:85097460523

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 10

M1 - 108473

ER -

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Abstract

Bibliographical note

UN SDGs

Keywords

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