Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity

Edward Po Fan Chu; Chia Hung Lin; Candy Hsin Hua Cho; I. Fen Cheng; Tzu Chien Kuo; Ruei Ying Chen; Chia Nan Liao; Jen Chien Cheng; Jason Isheng Tsai; Po Chuan Wang; Shing Jyh Chang; Chia Ning Shen

doi:10.1016/j.scr.2020.102029

Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity

Edward Po Fan Chu, Chia Hung Lin, Candy Hsin Hua Cho, I. Fen Cheng, Tzu Chien Kuo, Ruei Ying Chen, Chia Nan Liao, Jen Chien Cheng, Jason Isheng Tsai, Po Chuan Wang, Shing Jyh Chang, Chia Ning Shen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

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Abstract

Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity.

Original language	English
Article number	102029
Journal	Stem Cell Research
Volume	49
DOIs	https://doi.org/10.1016/j.scr.2020.102029
State	Published - 12 2020
Externally published	Yes

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© 2020 The Authors

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Chu, E. P. F., Lin, C. H., Cho, C. H. H., Cheng, I. F., Kuo, T. C., Chen, R. Y., Liao, C. N., Cheng, J. C., Tsai, J. I., Wang, P. C., Chang, S. J., & Shen, C. N. (2020). Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity. Stem Cell Research, 49, Article 102029. https://doi.org/10.1016/j.scr.2020.102029

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title = "Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity",

abstract = "Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity.",

author = "Chu, {Edward Po Fan} and Lin, {Chia Hung} and Cho, {Candy Hsin Hua} and Cheng, {I. Fen} and Kuo, {Tzu Chien} and Chen, {Ruei Ying} and Liao, {Chia Nan} and Cheng, {Jen Chien} and Tsai, {Jason Isheng} and Wang, {Po Chuan} and Chang, {Shing Jyh} and Shen, {Chia Ning}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = dec,

doi = "10.1016/j.scr.2020.102029",

language = "英语",

volume = "49",

journal = "Stem Cell Research",

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T1 - Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity

AU - Chu, Edward Po Fan

AU - Lin, Chia Hung

AU - Cho, Candy Hsin Hua

AU - Cheng, I. Fen

AU - Kuo, Tzu Chien

AU - Chen, Ruei Ying

AU - Liao, Chia Nan

AU - Cheng, Jen Chien

AU - Tsai, Jason Isheng

AU - Wang, Po Chuan

AU - Chang, Shing Jyh

AU - Shen, Chia Ning

PY - 2020/12

Y1 - 2020/12

N2 - Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity.

AB - Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity.

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DO - 10.1016/j.scr.2020.102029

M3 - 文章

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AN - SCOPUS:85092925313

SN - 1873-5061

VL - 49

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102029

ER -

Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity

Abstract

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