Abstract
Kawasaki disease (KD) primarily affects children <5 years of age (75%–80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Hospitalization rates of KD in US children aged 0–4 years (n = 10,880) and blood Hg levels in US children aged 1–5 years (n = 713) were determined using separate US federal datasets. Our cohort primarily presented with blood Hg levels <0.1 micrograms (μg) per kg bodyweight (96.5%) that are considered normal and subtoxic. Increased ethnic KD risk was significantly associated with both increasing levels and detection rates of blood Hg or cadmium (Cd) in a linear dose-responsive manner between ethnic African, Asian, Caucasian, and Hispanic children in the US (p ⩽ 0.05). Increasing low-dose exposure to Hg or Cd may induce KD or contribute to its later development in susceptible children. However, our preliminary results require further replication in other ethnic populations, in addition to more in-depth examination of metal exposure and toxicokinetics.
Original language | English |
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Article number | 101 |
Journal | International Journal of Environmental Research and Public Health |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 05 01 2016 |
Bibliographical note
Publisher Copyright:© 2016 by the authors; licensee MDPI, Basel, Switzerland.
Keywords
- Allergy
- Autoimmunity
- Infantile acrodynia
- Kawasaki disease
- Mercury
- Methylmercury
- Pediatrics
- Pollution
- Seafood
- Toxicology