Etonitazene: An opioid selective for the mu receptor types

Marjorie S. Moolten; Jordan B. Fishman; Jin Chung Chen; Kristin R. Carlson

doi:10.1016/0024-3205(93)90118-M

Etonitazene: An opioid selective for the mu receptor types

Marjorie S. Moolten
, Jordan B. Fishman
, Jin Chung Chen
, Kristin R. Carlson^*

^*Corresponding author for this work

University of Massachusetts Medical School

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu₁, mu₂, delta, kappa₁ and sigma receptors. Both etonitazene and morphine displayed a mu₁-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests.

Original language	English
Pages (from-to)	PL199-PL203
Journal	Life Sciences
Volume	52
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(93)90118-M
State	Published - 1993
Externally published	Yes

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title = "Etonitazene: An opioid selective for the mu receptor types",

abstract = "Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu1, mu2, delta, kappa1 and sigma receptors. Both etonitazene and morphine displayed a mu1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests.",

author = "Moolten, \{Marjorie S.\} and Fishman, \{Jordan B.\} and Chen, \{Jin Chung\} and Carlson, \{Kristin R.\}",

year = "1993",

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AU - Moolten, Marjorie S.

AU - Fishman, Jordan B.

AU - Chen, Jin Chung

AU - Carlson, Kristin R.

PY - 1993

Y1 - 1993

N2 - Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu1, mu2, delta, kappa1 and sigma receptors. Both etonitazene and morphine displayed a mu1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests.

AB - Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu1, mu2, delta, kappa1 and sigma receptors. Both etonitazene and morphine displayed a mu1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests.

UR - https://www.scopus.com/pages/publications/0027409071

U2 - 10.1016/0024-3205(93)90118-M

DO - 10.1016/0024-3205(93)90118-M

M3 - 文章

C2 - 8097861

AN - SCOPUS:0027409071

SN - 0024-3205

VL - 52

SP - PL199-PL203

JO - Life Sciences

JF - Life Sciences

IS - 18

ER -

Etonitazene: An opioid selective for the mu receptor types

Abstract

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