Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta

Tzu Zin Huang; Bo Wei Chen; Chiung Yao Huang; Tsong Long Hwang; Chang Feng Dai; Jyh Horng Sheu

doi:10.3390/md12052446

Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta

Tzu Zin Huang
, Bo Wei Chen
, Chiung Yao Huang
, Tsong Long Hwang
, Chang Feng Dai
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Sun Yat-sen University
National Taiwan University
Kaohsiung Medical University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Original language	English
Pages (from-to)	2446-2457
Number of pages	12
Journal	Marine Drugs
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/md12052446
State	Published - 05 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammatory activity
Cladiella hirsuta
Cytotoxic activity
Eunicellins
Soft coral

Access to Document

10.3390/md12052446

Cite this

@article{ecd4546a05f343149440b1cf3aca4d12,

title = "Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta",

abstract = "New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.",

keywords = "Anti-inflammatory activity, Cladiella hirsuta, Cytotoxic activity, Eunicellins, Soft coral",

author = "Huang, \{Tzu Zin\} and Chen, \{Bo Wei\} and Huang, \{Chiung Yao\} and Hwang, \{Tsong Long\} and Dai, \{Chang Feng\} and Sheu, \{Jyh Horng\}",

year = "2014",

month = may,

doi = "10.3390/md12052446",

language = "英语",

volume = "12",

pages = "2446--2457",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

}

TY - JOUR

T1 - Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta

AU - Huang, Tzu Zin

AU - Chen, Bo Wei

AU - Huang, Chiung Yao

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Sheu, Jyh Horng

PY - 2014/5

Y1 - 2014/5

N2 - New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

AB - New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

KW - Anti-inflammatory activity

KW - Cladiella hirsuta

KW - Cytotoxic activity

KW - Eunicellins

KW - Soft coral

UR - https://www.scopus.com/pages/publications/84901462288

U2 - 10.3390/md12052446

DO - 10.3390/md12052446

M3 - 文章

C2 - 24796303

AN - SCOPUS:84901462288

SN - 1660-3397

VL - 12

SP - 2446

EP - 2457

JO - Marine Drugs

JF - Marine Drugs

IS - 5

ER -

Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this