Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta

Tzu Zin Huang; Bo Wei Chen; Chiung Yao Huang; Tsong Long Hwang; Chokkalingam Uvarani; Chang Feng Dai; Ping Jyun Sung; Jui Hsin Su; Jyh Horng Sheu

doi:10.3390/md13052757

Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta

Tzu Zin Huang
, Bo Wei Chen
, Chiung Yao Huang
, Tsong Long Hwang
, Chokkalingam Uvarani
, Chang Feng Dai
, Ping Jyun Sung
, Jui Hsin Su
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Sun Yat-sen University
Chang Gung University of Science and Technology
National Museum of Marine Biology and Aquarium, Taiwan
National Taiwan University
National Dong Hwa University
Kaohsiung Medical University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Original language	English
Pages (from-to)	2757-2769
Number of pages	13
Journal	Marine Drugs
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/md13052757
State	Published - 01 05 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammatory activity
Cladiella hirsuta
Cytotoxic activity
Eunicellins
Soft coral

Access to Document

10.3390/md13052757

Cite this

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title = "Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta",

abstract = "Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.",

keywords = "Anti-inflammatory activity, Cladiella hirsuta, Cytotoxic activity, Eunicellins, Soft coral",

author = "Huang, \{Tzu Zin\} and Chen, \{Bo Wei\} and Huang, \{Chiung Yao\} and Hwang, \{Tsong Long\} and Chokkalingam Uvarani and Dai, \{Chang Feng\} and Sung, \{Ping Jyun\} and Su, \{Jui Hsin\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2015 by the authors; licensee MDPI.",

year = "2015",

month = may,

day = "1",

doi = "10.3390/md13052757",

language = "英语",

volume = "13",

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T1 - Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta

AU - Huang, Tzu Zin

AU - Chen, Bo Wei

AU - Huang, Chiung Yao

AU - Hwang, Tsong Long

AU - Uvarani, Chokkalingam

AU - Dai, Chang Feng

AU - Sung, Ping Jyun

AU - Su, Jui Hsin

AU - Sheu, Jyh Horng

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

AB - Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

KW - Anti-inflammatory activity

KW - Cladiella hirsuta

KW - Cytotoxic activity

KW - Eunicellins

KW - Soft coral

UR - https://www.scopus.com/pages/publications/84930653674

U2 - 10.3390/md13052757

DO - 10.3390/md13052757

M3 - 文章

C2 - 25942094

AN - SCOPUS:84930653674

SN - 1660-3397

VL - 13

SP - 2757

EP - 2769

JO - Marine Drugs

JF - Marine Drugs

IS - 5

ER -

Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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