Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity

Yu Hsuan Lan; I. Hsiao Chen; Hsin Hung Lu; Ting Jing Guo; Tsong Long Hwang; Yann Lii Leu

doi:10.3390/molecules27061885

Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity

Yu Hsuan Lan^*, I. Hsiao Chen, Hsin Hung Lu, Ting Jing Guo, Tsong Long Hwang, Yann Lii Leu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 sig-nificantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Further-more, compounds 25 and 33 displayed the most potent effects with IC₅₀ values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).

Original language	English
Article number	1885
Journal	Molecules
Volume	27
Issue number	6
DOIs	https://doi.org/10.3390/molecules27061885
State	Published - 01 03 2022

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Euphorbia formosana Hayata
Euphorbiaceae
anti-inflammatory
euphormins
pyranocoumarin derivatives

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title = "Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity",

abstract = "Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 sig-nificantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Further-more, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).",

keywords = "Euphorbia formosana Hayata, Euphorbiaceae, anti-inflammatory, euphormins, pyranocoumarin derivatives",

author = "Lan, {Yu Hsuan} and Chen, {I. Hsiao} and Lu, {Hsin Hung} and Guo, {Ting Jing} and Hwang, {Tsong Long} and Leu, {Yann Lii}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = mar,

day = "1",

doi = "10.3390/molecules27061885",

language = "英语",

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AU - Lan, Yu Hsuan

AU - Chen, I. Hsiao

AU - Lu, Hsin Hung

AU - Guo, Ting Jing

AU - Hwang, Tsong Long

AU - Leu, Yann Lii

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 sig-nificantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Further-more, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).

AB - Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 sig-nificantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Further-more, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).

KW - Euphorbia formosana Hayata

KW - Euphorbiaceae

KW - anti-inflammatory

KW - euphormins

KW - pyranocoumarin derivatives

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U2 - 10.3390/molecules27061885

DO - 10.3390/molecules27061885

M3 - 文章

C2 - 35335252

AN - SCOPUS:85126909988

SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

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M1 - 1885

ER -

Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity

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