Evaluation of [99mTc] liposomes as lymphoscintigraphic agents: Comparison with [99mTc] sulfur colloid and [99mTc] human serum albumin

William T. Phillips; Trevor Andrews; Ho Ling Liu; Robert Klipper; Alfred J. Landry; Ralph Blumhardt; Beth Goins

doi:10.1016/S0969-8051(01)00198-6

Evaluation of [^99mTc] liposomes as lymphoscintigraphic agents: Comparison with [^99mTc] sulfur colloid and [^99mTc] human serum albumin

William T. Phillips^*, Trevor Andrews, Ho Ling Liu, Robert Klipper, Alfred J. Landry, Ralph Blumhardt, Beth Goins

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

29 Scopus citations

Abstract

This study investigates the use of [^99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [^99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [^99mTc] regular-sulfur colloid (SC), [^99mTc] 0.22 μ-filtered-SC, [^99mTc] reduced heating time 0.22 μ-filtered-SC, and [^99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [^99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [^99mTc] filtered SC preparations > [^99mTc] regular SC > [^99mTc] liposomes > [^99mTc] HSA. [^99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.

Original language	English
Pages (from-to)	435-444
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/S0969-8051(01)00198-6
State	Published - 2001
Externally published	Yes

Keywords

HMPAO
Liposomes
Lymphoscintigraphy
Sentinel node
Technetium-99m

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0969-8051(01)00198-6

Cite this

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title = "Evaluation of [99mTc] liposomes as lymphoscintigraphic agents: Comparison with [99mTc] sulfur colloid and [99mTc] human serum albumin",

abstract = "This study investigates the use of [99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [99mTc] regular-sulfur colloid (SC), [99mTc] 0.22 μ-filtered-SC, [99mTc] reduced heating time 0.22 μ-filtered-SC, and [99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [99mTc] filtered SC preparations > [99mTc] regular SC > [99mTc] liposomes > [99mTc] HSA. [99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.",

keywords = "HMPAO, Liposomes, Lymphoscintigraphy, Sentinel node, Technetium-99m",

author = "Phillips, {William T.} and Trevor Andrews and Liu, {Ho Ling} and Robert Klipper and Landry, {Alfred J.} and Ralph Blumhardt and Beth Goins",

year = "2001",

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AU - Andrews, Trevor

AU - Liu, Ho Ling

AU - Klipper, Robert

AU - Landry, Alfred J.

AU - Blumhardt, Ralph

AU - Goins, Beth

PY - 2001

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N2 - This study investigates the use of [99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [99mTc] regular-sulfur colloid (SC), [99mTc] 0.22 μ-filtered-SC, [99mTc] reduced heating time 0.22 μ-filtered-SC, and [99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [99mTc] filtered SC preparations > [99mTc] regular SC > [99mTc] liposomes > [99mTc] HSA. [99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.

AB - This study investigates the use of [99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [99mTc] regular-sulfur colloid (SC), [99mTc] 0.22 μ-filtered-SC, [99mTc] reduced heating time 0.22 μ-filtered-SC, and [99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [99mTc] filtered SC preparations > [99mTc] regular SC > [99mTc] liposomes > [99mTc] HSA. [99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.

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